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Noviembre 2012 PDF Imprimir E-mail
Miércoles, 05 de Diciembre de 2012 00:00

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SELECCIÓN DE REFERENCIAS BIBLIOGRÁFICAS DE LO PUBLICADO EN RELACIÓN CON ATENCIÓN PRIMARIA

Selección realizada por Antonio Manteca González 

ACADEMIC MEDICINE

 

Bickel J. Focus on improving relational communication skills and discussing what matters most. Acad Med. 2012; 87:1471-1472 [AO,I]

23111261

ENFOQUE SOBRE LA MEJORÍA DE LAS HABILIDADES DE COMUNICACIÓN RELACIONALES Y DEBATE SOBRE QUÉ ES LO QUE IMPORTA MÁS

 

Dhaliwal G. Clinical excellence: make it a habit. Acad Med. 2012; 87:1473 [AO,I]

23111262

EXCELENCIA CLÍNICA: HÁGANLA UNA COSTUMBRE

 

Dodge C, Sherwood EJ, Shomaker TS. Organizational performance and teamwork: achieving interactive excellence. Acad Med. 2012; 87:1474 [AO,I]

23111263

RENDIMIENTO ORGANIZATIVO Y TRABAJO EN EQUIPO: ALCANZAR LA EXCELENCIA INTERACTIVA

 

ANNALS OF INTERNAL MEDICINE

 

Roumie CL, Hung AM, Greevy RA, Grijalva CG, Liu X, Murff HJ, et al. Comparative effectiveness of sulfonylurea and metformin monotherapy on cardiovascular events in type 2 diabetes mellitus: a cohort study. Ann Intern Med 2012; 157:601-610 [S,II]

23128859             R/C

EFECTIVIDAD COMPARADA DE LA MONOTERAPIA CON SULFONILUREA Y CON METFORMINA SOBRE LOS ACONTECIMIENTOS CARDIOVASCULARES EN LA DIABETES MELLITUS TIPO 2: ESTUDIO DE COHORTES

 

Knudsen AB, Hur C, Gazelle GS, Schrag D, McFarland EG, Kuntz KM. Rescreening of persons with a negative colonoscopy result: results from a microsimulation model. Ann Intern Med 2012;157:611-620 [T,I]

23128861             R/C

RECRIBAJE DE PERSONAS CON RESULTADO NEGATIVO EN LA COLONOSCOPIA: RESULTADOS DE UN MODELO DE MICROSIMULACIÓN

 

Wang SY, Olson-Kellogg B, Shamliyan TA, Choi JY, Ramakrishnan R, Kane RL. Physical therapy interventions for knee pain secondary to osteoarthritis: a systematic review. Ann Intern Med 2012;157:632-644 [M,II]

23128863             R/C

INTERVENCIONES DE TERAPIA FÍSICA SOBRE EL DOLOR DE RODILLA SECUNDARIO A ARTROSIS: REVISIÓN SISTEMÁTICA

 

Lederle FA, Bloomfield HE. Drug treatment of asymptomatic hypertriglyceridemia to prevent pancreatitis: where is the evidence? Ann Intern Med 2012;157:662-664 [AO,II]

23128864

TRATAMIENTO FARMACOLÓGICO DE LA HIPERTRIGLIDERIDEMIA ASINTOMÁTICA PARA PREVENIR LA PANCREATITIS: ¿DÓNDE ESTÁ LA EVIDENCIA?

 

Nissen SE. Cardiovascular effects of diabetes drugs: emerging from the dark ages. Ann Intern Med 2012;157:671-672 [AO,I]

23128866

EFECTOS CARDIOVASCULARES DE LOS FÁRMACOS PARA LA DIABETES: EMERGER DE LOS TIEMPOS OSCUROS

 

Weinberg DS, Schoen RE. Colorectal cancer screening: America's next top model? Ann Intern Med 2012;157:673-674 [AO,I]

23128867

CRIBAJE DEL CÁNCER COLORRECTAL: ¿PRÓXIMO TOP MODEL DE AMÉRICA?

 

Chou R, Selph S, Dana T, Bougatsos C, Zakher B, Blazina I, et al. Screening for HIV: systematic review to update the 2005 U.S. Preventive Services Task Force recommendation. Ann Intern Med 2012;157:706-718 [M,II]

23165662             R/C

CRIBAJE DEL VIH: REVISIÓN SISTEMÁTICA PARA ACTUALIZAR LA RECOMENDACIÓN DE 2005 DEL U.S. PREVENTIVE SERVICES TASK FORCE

 

Qaseem A, Fihn SD, Dallas P, Williams S, Owens DK, Shekelle P; for the Clinical Guidelines Committee of the American College of Physicians*. Management of stable ischemic heart disease: summary of a Clinical Practice Guideline from the American College of Physicians/American College of Cardiology Foundation/American Heart Association/American Association for Thoracic Surgery/Preventive Cardiovascular Nurses Association/Society of Thoracic Surgeons. Ann Intern Med 2012;157:735-743 [M,II]

23165665             R/C

MANEJO DE LA ENFERMEDAD ISQUÉMICA CARDIACA ESTABLE: RESUMEN DE UNA GUÍA

DE PRÁCTICA CLÍNICA DEL AMERICAN COLLEGE OF PHYSICIANS/AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION/AMERICAN HEART ASSOCIATION/AMERICAN ASSOCIATION FOR THORACIC SURGERY/PREVENTIVE CARDIOVASCULAR NURSES ASSOCIATION/SOCIETY OF THORACIC SURGEONS

 

Kussmaul WG. Guidelines on diagnosis and treatment of stable ischemic heart disease: keeping up with a constantly evolving evidence base. Ann Intern Med 2012;157:749-751 [AO,I]

23165667

GUÍAS SOBRE DIAGNÓSTICO Y TRATAMIENTO DE LA ENFERMEDAD CARDIACA ISQUÉMICA ESTABLE: SEGUIR ADELANTE CON UNA BASE DE EVIDENCIA EN CONSTANTE EVOLUCIÓN

 

Jonas DE, Garbutt JC, Amick HR, Brown JM, Brownley KA, Council CL, et al. Behavioral counseling after screening for alcohol misuse in primary care: a systematic review and meta-analysis for the U.S. Preventive Services Task Force. Ann Intern Med 2012 [Epub ahead of print] [M,II]

23007881             R/C

CONSEJO CONDUCTUAL TRAS EL CRIBAJE SOBRE USO INADECUADO DE ALCOHOL EN ATENCIÓN PRIMARIA: REVISIÓN SISTEMÁTICA Y METAANÁLISIS DEL U.S. PREVENTIVE SERVICES TASK FORCE

 

Wallace EA, Schumann JH, Weinberger SE. Ethics of commercial screening tests. Ann Intern Med 2012[Epub ahead of print] [AO,I]

22928174

ÉTICA DE LAS PRUEBAS DE CRIBAJE COMERCIALES

 

Paltiel AD, Walensky RP. Home HIV testing: good news but not a game changer. Ann Intern Med 2012  [Epub ahead of print] [AO,I]

23044643

PRUEBA CASERA DE VIH: BUENAS NOTICIAS, PERO NO UN CAMBIO RADICAL

 

Moyer VA; on behalf of the U.S. Preventive Services Task Force. Screening for hearing loss in older adults: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 2012 [Epub ahead of print] [M,II]

22893115             R/C

CRIBAJE DE PÉRDIDA DE AUDICIÓN EN ANCIANOS: DECLARACIÓN DE RECOMENDACIÓN DEL U.S. PREVENTIVE SERVICES TASK FORCE

 

ARCHIVOS DE BRONCONEUMOLOGIA

 

Vieira SE, Stein RT, Ferraro AA, Pastro LD, Cosme Pedro SS, Lemos M et al. Los contaminantes atmosféricos urbanos son factores de riesgo significativos para el asma y la neumonía en niños: influencia del lugar de medición de los contaminantes. Arch Bronconeumol 2012;48:389-395 [T,I]

                R/C

LOS CONTAMINANTES ATMOSFÉRICOS URBANOS SON FACTORES DE RIESGO SIGNIFICATIVOS PARA EL ASMA Y LA NEUMONÍA EN NIÑOS: INFLUENCIA DEL LUGAR DE MEDICIÓN DE LOS CONTAMINANTES

 

ARCHIVES OF GENERAL PSYCHIATRY

 

Sullivan PF, Magnusson C, Reichenberg A, Boman M, Dalman C, Davidson M, et al. Family history of schizophrenia and bipolar disorder as risk factors for autism. Arch Gen Psychiatry. 2012:1-5 [Epub ahead of print] [CC,I]

22752149            R/C

HISTORIA FAMILIAR DE ESQUIZOFRENIA Y TRASTORNO BIPOLAR COMO FACTORES DE RIESGO DE AUTISMO

 

ARCHIVES OF INTERNAL MEDICINE

 

O'Donnell MJ, Fang J, D'Uva C, Saposnik G, Gould L, McGrath E, et al; for the Investigators of the Registry of the Canadian Stroke Network. The PLAN score: a bedside prediction rule for death and severe disability following acute ischemic stroke. Arch Intern Med. 2012; 172:1548-1556 [S,II]

23147454             R/C

LA TABLA PLAN: UNA REGLA DE CABECERA PARA PREDECIR LA MUERTE Y DISCAPACIDAD GRAVE TRAS ICTUS ISQUÉMICO AGUDO

 

Gadde KM, Kopping MF, Wagner HR, Yonish GM, Allison DB, Bray GA. Zonisamide for weight reduction in obese adults: a 1-year randomized controlled trial. Arch Intern Med. 2012; 172:1557-1564 [EC,I]

23147455             R/C

ZONISAMIDA PARA LA LA REDUCCIÓN DE PESO EN ADULTOS OBESOS: ENSAYO ALEATORIZADO CONTROLADO DE 1 AÑO

 

Hernandez AV. No place for novel oral anticoagulants in current treatment of acute coronary syndromes: comment on "Use of new-generation oral anticoagulant agents in patients receiving antiplatelet therapy after an acute coronary syndrome" Arch Intern Med. 2012:1-2 [Epub ahead of print] [AO,I]

23007954

NO HAY LUGAR PARA LOS NUEVOS ANTICOAGULANTES ORALES EN EL TRATAMIENTO ACTUAL DE LOS SÍNDROMES CORONARIOS AGUDOS: COMENTARIO SOBRE "USO DE AGENTES ANTICOAGULANTES ORALES DE NUEVA GENERACIÓN EN PACIENTES QUE RECIBEN TRATAMIENTO ANTIPLAQUETARIO TRAS UN SÍNDROME CORONARIO AGUDO"

 

Komócsi A, Vorobcsuk A, Kehl D, Aradi D. Use of new-generation oral anticoagulant agents in patients receiving antiplatelet therapy after an acute coronary syndrome: systematic review and meta-analysis of randomized controlled trials. Arch Intern Med. 2012:1-9 [Epub ahead of print] [M,II]

23007264            R/C

USO DE AGENTES ANTICOAGULANTES ORALES DE NUEVA GENERACIÓN EN PACIENTES QUE RECIBEN TRATAMIENTO ANTIPLAQUETARIO TRAS UN SÍNDROME CORONARIO AGUDO: REVISIÓN SISTEMÁTICA Y METAANÁLISIS DE ENSAYOS CONTROLADOS ALEATORIZADOS

 

ATENCION PRIMARIA

 

Córdoba R, Camarelles F, Lizarbe V, Jiménez M. Abordaje del consumo de riesgo de alcohol desde atención primaria. Aten Primaria. 2012; 44:635-637 [R,I]

23101564

ABORDAJE DEL CONSUMO DE RIESGO DE ALCOHOL DESDE ATENCIÓN PRIMARIA

 

Carratalá-Munuera MC, Orozco-Beltrán D, Gil-Guillen VF, Navarro-Perez J, Quirce F, Merino J, Basora J. Análisis bibliométrico de la producción científica internacional sobre atención primaria. Aten Primaria. 2012; 44:651-658 [T,I]

22296794             R/C

ANÁLISIS BIBLIOMÉTRICO DE LA PRODUCCIÓN CIENTÍFICA INTERNACIONAL SOBRE ATENCIÓN PRIMARIA

               

Castañal-Canto X, Martín-Miguel MV, Hervés-Beloso C, Pérez-Cachafeiro S, Espinosa-Arévalo MM, Delgado-Martín JL. Trabajando con nuestros pacientes fumadores en atención primaria. Un análisis de coste-efectividad. Aten Primaria. 2012; 44:659-666 [CE,I]

22704941             R/C

TRABAJANDO CON NUESTROS PACIENTES FUMADORES EN ATENCIÓN PRIMARIA. UN ANÁLISIS DE COSTE-EFECTIVIDAD

 

Abella F, Córdoba R, Suárez MP. Salud, hostelería e industria del tabaco. Aten Primaria. 2012; 44:676-681 [R,I]

22257526             R/C

SALUD, HOSTELERÍA E INDUSTRIA DEL TABACO

 

Pallás C, Ureta N, Alonso C; grupo PAPPS Infancia y Adolescencia de semFYC. Suplementación de vitamina D en la infancia. Aten Primaria. 2012; 44:682-683 [AO,I]

22858564

SUPLEMENTACIÓN DE VITAMINA D EN LA INFANCIA

 

BRITISH JOURNAL OF PSYCHIATRY

 

de Jonge P, Roest AM. Depression and cardiovascular disease: the end of simple models. Br J Psychiatry. 2012; 201:337-338 [AO,I]

23118031             R/C

DEPRESIÓN Y ENFERMEDAD CARDIOVASCULAR: EL FIN DE LOS MODELOS SIMPLES

 

Berk M, Jacka F. Preventive strategies in depression: gathering evidence for risk factors and potential interventions. Br J Psychiatry. 2012; 201:339-341 [AO,I]

23118032             R/C

ESTRATEGIAS PREVENTIVAS EN LA DEPRESIÓN: REUNIR EVIDENCIA SOBRE LOS FACTORES DE RIESGO Y LAS INTERVENCIONES POTENCIALES

 

Orrell M. The new generation of psychosocial interventions for dementia care. Br J Psychiatry. 2012; 201:342-343 [AO,I]

23118033             R/C

LA NUEVA GENERACIÓN DE INTERVENCIONES PSICOSOCIALES EN LA ATENCIÓN A LA DEMENCIA

 

Lawrence V, Fossey J, Ballard C, Moniz-Cook E, Murray J. Improving quality of life for people with dementia in care homes: making psychosocial interventions work. Br J Psychiatry. 2012; 201:344-351 [M,II]

23118034             R/C

MEJORAR LA CALIDAD DE VIDA DE LAS PERSONAS CON DEMENCIA EN LOS HOGARES DE CUIDADOS: PONER A FUNCIONAR LAS INTERVENCIONES PSICOSOCIALES

 

Aberg MA, Waern M, Nyberg J, Pedersen NL, Bergh Y, Aberg ND, et al. Cardiovascular fitness in males at age 18 and risk of serious depression in adulthood: Swedish prospective population-based study. Br J Psychiatry. 2012 ;201:352-359 [S,I]

22700083             R/C

ESTADO DE FORMA CARDIOVASCULAR EN HOMBRES A LOS 18 AÑOS Y RIESGO DE DEPRESIÓN GRAVE EN LA EDAD ADULTA: ESTUDIO POBLACIONAL PROSPECTIVO SUECO

 

Kjærgaard M, Waterloo K, Wang CE, Almås B, Figenschau Y, Hutchinson MS, et al. Effect of vitamin D supplement on depression scores in people with low levels of serum 25-hydroxyvitamin D: nested case-control study and randomised clinical trial. Br J Psychiatry. 2012; 201:360-368 [EC,I]

22790678             R/C

EFECTO DE LOS SUPLEMENTOS DE VITAMINA D SOBRE LAS PUNTUACIONES DE DEPRESIÓN EN PERSONAS CON NIVELES BAJOS DE 25-HIDROXIVITAMINA D: ESTUDIO CASO-CONTROL ANIDADO Y ENSAYO CLÍNICO ALEATORIZADO

 

BRITISH MEDICAL JOURNAL

 

Ford AC, Talley NJ. Laxatives for chronic constipation in adults. BMJ. 2012; 345:e6168 [R,I]

23028096

LAXANTES EN EL ESTREÑIMIENTO CRÓNICO EN ADULTOS

 

Schierbeck LL, Rejnmark L, Tofteng CL, Stilgren L, Eiken P, Mosekilde L, et al. Effect of hormone replacement therapy on cardiovascular events in recently postmenopausal women: randomised trial. BMJ. 2012; 345:e6409 [EC,II]

23048011             R/C

EFECTO DE LA TERAPIA HORMONAL SUSTITUTIVA SOBRE LOS ACONTECIMIENTOS CARDIOVASCULARES EN MUJERES CON MENOPAUSIA RECIENTE: ENSAYO ALEATORIZADO

 

Gringras P, Gamble C, Jones AP, Wiggs L, Williamson PR, Sutcliffe A, et al; on behalf of the MENDS Study Group. Melatonin for sleep problems in children with neurodevelopmental disorders: randomised double masked placebo controlled trial. BMJ. 2012; 345:e6664 [EC,II]

23129488             R/C

MELATONINA EN LOS PROBLEMAS DE SUEÑO EN NIÑOS CON TRASTORNOS  DEL DESARROLLO NEUROLÓGICO: ENSAYO CONTROLADO ALEATORIZADO DOBLEMENTE ENMASCARADO CON PLACEBO

 

Chowdhury R, Stevens S, Gorman D, Pan A, Warnakula S, Chowdhury S, et al. Association between fish consumption, long chain omega 3 fatty acids, and risk of cerebrovascular disease: systematic review and meta-analysis. BMJ. 2012; 345:e6698 [M,II]

23112118             R/C

ASOCIACIÓN ENTRE CONSUMO DE PESCADO, ÁCIDOS GRASOS OMEGA 3 DE CADENA LARGA Y RIESGO DE ENFERMEDAD CEREBROVASCULAR: REVISIÓN SISTEMÁTICA Y METAANÁLISIS

 

Schuetz GM, Schlattmann P, Dewey M. Use of 3x2 tables with an intention to diagnose approach to assess clinical performance of diagnostic tests: meta-analytical evaluation of coronary CT angiography studies. BMJ. 2012; 345:e6717 [M,II]

23097549             R/C

USO DE TABLAS 3x2 CON INTENCIÓN DE ABORDAJE DIAGNÓSTICO PARA VALORAR EL RENDIMIENTO DE LAS PRUEBAS DIAGNÓSTICAS: EVALUACIÓN METAANALÍTICA DE LOS ESTUDIOS DE ANGIOTAC CORONARIA

 

Abubakar I, Griffiths C, Ormerod P; on behalf of the Guideline Development Group. Diagnosis of active and latent tuberculosis: summary of NICE guidance. BMJ. 2012; 345:e6828 [M,III]

23077351

DIAGNÓSTICO DE TUBERCULOSIS LATENTE Y ACTIVA: RESUMEN DE LA GUÍA NICESmed

 

Park HY, Man SF, Sin DD. Inhaled corticosteroids for chronic obstructive pulmonary disease. BMJ. 2012; 345:e6843 [R,I]

23100329

CORTICOIDES INHALADOS EN LA EPOC

 

Rozenbaum MH, van Hoek AJ, Fleming D, Trotter CL, Miller E, Edmunds WJ. Vaccination of risk groups in England using the 13 valent pneumococcal conjugate vaccine: economic analysis. BMJ. 2012; 345:e6879 [CE,I]

23103369             R/C

VACUNACIÓN DE GRUPOS DE RIESGO EN INGLATERRA CON VACUNA CONJUGADA NEUMOCÓCICA 13-VALENTE: ANÁLISIS ECONÓMICO

 

Smed S, Robertson A. Are taxes on fatty foods having their desired effects on health? BMJ. 2012; 345:e6885 [AO,I]

23077325

¿ESTÁN TENIENDO LOS IMPUESTOS SOBRE LAS COMIDAS GRASAS SUS EFECTOS DESEADOS SOBRE LA SALUD?

 

Lerchl A, Reiter RJ. Treatment of sleep disorders with melatonin. BMJ. 2012; 345:e6968 [R,I]

23129489

TRATAMIENTO DE LOS TRASTORNOS DEL SUEÑO CON MELATONINA

 

Ah-See KL, Mackenzie J, Practitioner G, Ah-See KW. Management of chronic rhinosinusitis. BMJ. 2012; 345:e7054 [R,I]

23111434

MANEJO DE LA RINOSINUSITIS CRÓNICA

 

Sakata R, McGale P, Grant EJ, Ozasa K, Peto R, Darby SC. Impact of smoking on mortality and life expectancy in Japanese smokers: a prospective cohort study. BMJ. 2012; 345:e7093 [S,II]

23100333             R/C

IMPACTO DEL TABACO SOBRE LA MORTALIDAD Y LA EXPECTATIVA DE VIDA DE LOS JAPONESES FUMADORES: ESTUDIO DE COHORTES PROSPECTIVO

 

Rasmussen LH, Larsen TB, Graungaard T, Skjøth F, Lip GY. Primary and secondary prevention with new oral anticoagulant drugs for stroke prevention in atrial fibrillation: indirect comparison analysis. BMJ. 2012; 345:e7097 [M,II]

23129490            R/C

PREVENCIÓN PRIMARIA Y SECUNDARIA CON NUEVOS FÁRMACOS ANTICOAGULANTES PARA LA PREVENCIÓN DEL ICTUS EN LA FIBRILACIÓN AURICULAR: ANÁLISIS DE COMPARACIÓN INDIRECTO

 

Appleby J. Rises in healthcare spending: where will it end? BMJ. 2012; 345:e7127 [AO,]

23118304

SUBIDAS EN EL GASTO DE LA ATENCIÓN SANITARIA: ¿DÓNDE ACABARÁ?

 

Gruen RL, Reade MC. Administer tranexamic acid early to injured patients at risk of substantial bleeding. BMJ. 2012; 345:e7133 [AO,I]

23165649

ADMINISTRAR ÁCIDO TRANEXÁMICO DE FORMA PRECOZ A LOS PACIENTES HERIDOS CON RIESGO DE SANGRADO SUSTANCIAL

 

Svanström H, Pasternak B, Hviid A. Use of varenicline for smoking cessation and risk of serious cardiovascular events: nationwide cohort study. BMJ. 2012; 345:e7176 [S,I]

23138033             R/C

USO DE VARENICLINA PARA DEJAR DE FUMAR Y RIESGO DE ACONTECIMIENTOS CARDIOVASCULARES GRAVES: ESTUDIO DE COHORTES NACIONAL

 

Krogsbøll LT, Jørgensen KJ, Grønhøj Larsen C, Gøtzsche PC. General health checks in adults for reducing morbidity and mortality from disease: Cochrane systematic review and meta-analysis. BMJ. 2012; 345:e7191 [M,II]

23169868             R/C

REVISIONES DE SALUD GENERAL EN ADULTOS PARA REDUCIR LA MORBILIDAD Y LA MORTALIDAD POR ENFERMEDAD: REVISIÓN SISTEMÁTICA COCHRANE Y METAANÁLISIS

 

de Goede J, Geleijnse JM. The role of fatty acids from fish in the prevention of stroke. BMJ. 2012; 345:e7219 [AO,I]

23112120

EL PAPEL DE LOS ÁCIDOS GRASOS DE PESCADO EN LA PREVENCIÓN DEL ICTUS

 

The doctor won't see you now: online consulting and prescribing. BMJ. 2012; 345:e7238 [AO,I]

23112121

EL DOCTOR NO LE VA A VER AHORA: CONSULTA Y PRESCRIPCIÓN ONLINE

 

Ortega FB, Silventoinen K, Tynelius P, Rasmussen F. Muscular strength in male adolescents and premature death: cohort study of one million participants. BMJ. 2012; 345:e7279 [S,I]

23169869             R/C

FUERZA MUSCULAR EN ADOLESCENTES MASCULINOS Y MUERTE PREMATURA: ESTUDIO DE COHORTES CON UN MILLÓN DE PARTICIPANTES

 

Farmer A. Use of HbA1c in the diagnosis of diabetes. BMJ. 2012; 345:e7293 [AO,I]

23118305

USO DE HBA1C EN EL DIAGNÓSTICO DE DIABETES

 

Godlee F. Clinical trial data for all drugs in current use. BMJ. 2012; 345:e7304 [AO,I]

23109483

DATOS DE ENSAYOS CLÍNICOS PARA TODOS LOS FÁRMACOS EN USO ACTUAL

 

Auth MK, Vora R, Farrelly P, Baillie C. Childhood constipation. BMJ. 2012; 345:e7309 [R,I]

23150472

ESTREÑIMIENTO EN LA INFANCIA

 

Beasley R, Singh S, Loke YK, Enright P, Furberg CD. Call for worldwide withdrawal of tiotropium Respimat mist inhaler. BMJ. 2012; 345:e7390 [R,II]

23144209

LLAMAMIENTO A LA RETIRADA MUNDIAL DEL INHALADOR NEBULIZADOR RESPIMAT CON TIOTROPIO

 

Myat A, Redwood SR, Qureshi AC, Spertus JA, Williams B. Resistant hypertension. BMJ. 2012; 345:e7473 [R,I]

23169802

HIPERTENSIÓN RESISTENTE

 

Fox BD, Kahn SR, Langleben D, Eisenberg MJ, Shimony A. Efficacy and safety of novel oral anticoagulants for treatment of acute venous thromboembolism: direct and adjusted indirect meta-analysis of randomised controlled trials. BMJ. 2012; 345:e7498 [M,II]

23150473             R/C

EFICACIA Y SEGURIDAD DE LOS NUEVOS ANTICOAGULANTES ORALES PARA EL TRATAMIENTO DEL TROMBOEMBOLISMO VENOSO AGUDO: METAANÁLISIS DIRECTO E INDIRECTO AJUSTADO DE ENSAYOS CONTROLADOS ALEATORIZADOS

 

Harrison-Woolrych M. Varenicline for smoking cessation. BMJ. 2012; 345:e7547 [AO,I]

23138037

VARENICLINA PARA DEJAR DE FUMAR

 

Boyd K, Murray S. Using end of life care pathways for the last hours or days of life. BMJ. 2012; 345:e7718 [AO,I]

23152575

USO DE PAUTAS EN EL FINAL DE LA VIDA PARA LAS ÚLTIMAS HORAS O LOS ÚLTIMOS DÍAS DE VIDA

 

Clark CE, McManus R. The use of highly structured care to achieve blood pressure targets. BMJ. 2012; 345:e7777 [AO,I]

23169804

USO DE ATENCIÓN FUERTEMENTE ESTRUCTURADA PARA ALCANZAR LOS OBJETIVOS DE PRESIÓN ARTERIAL

 

CANADIAN MEDICAL ASSOCIATION JOURNAL

 

Sibbald B, Holroyd-Leduc JM. Protecting our most vulnerable elders from abuse. CMAJ. 2012; 184:1763 [AO,I]

22988155

PROTEGER DEL MALTRATO A NUESTROS MAYORES MÁS VULNERABLES

 

Biskin RS, Paris J. Diagnosing borderline personality disorder. CMAJ. 2012; 184:1789-1794 [R,I]

22988153

DIAGNOSTICAR EL TRASTORNO DE PERSONALIDAD LIMÍTROFE

 

Warner E, Heisey R, Carroll JC. Applying the 2011 Canadian guidelines for breast cancer screening in practice. CMAJ. 2012; 184:1803-1807 [R,I]

22966059

APLICAR LAS GUÍAS CANADIENSES DE 2011 SOBRE CRIBAJE DE CÁNCER DE MAMA EN LA CONSULTA

 

Flegel K. Health care workers must protect patients from influenza by taking the annual vaccine. CMAJ. 2012; 184:1873 [AO,I]

23109612

LOS TRABAJADORES DE LA ATENCIÓN SANITARIA DEBEN PROTEGER A LOS PACIENTES DE LA GRIPE PONIÉNDOSE LA VACUNA ANUAL

 

Biskin RS, Paris J. Management of borderline personality disorder. CMAJ. 2012; 184:1897-1902 [R,I]

23027916

MANEJO DEL TRASTORNO DE PERSONALIDAD LIMÍTROFE

 

Liang Y, Mente A, Yusuf S, Gao P, Sleight P, Zhu J, et al; for the ONTARGET and TRANSCEND Investigators. Alcohol consumption and the risk of incident atrial fibrillation among people with cardiovascular disease. CMAJ. 2012; 184:E857-E866 [T,I]

23027910             R/C

CONSUMO DE ALCOHOL Y RIESGO DE APARICIÓN DE FIBRILACIÓN AURICULAR ENTRE PERSONAS CON ENFERMEDAD CARDIOVASCULAR

 

Scaranelo A. Breast screening with magnetic resonance imaging. CMAJ. 2012; 184:E877 [AO,I]

22802387

CRIBAJE DE CÁNCER DE MAMA CON RESONANCIA MAGNÉTICA

 

Persaud N, Coleman E, Zwolakowski D, Lauwers B, Cass D. Nonuse of bicycle helmets and risk of fatal head injury: a proportional mortality, case-control study. CMAJ. 2012; 184:E921-E923 [CC,I]

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NO USAR CASCOS DE BICICLETA Y RIESGO DE DAÑO MORTAL EN LA CABEZA: ESTUDIO DE CASO-CONTROL CON MORTALIDAD PROPORCIONAL

 

CIRCULATION

 

Tan CE, Glantz SA. Association between smoke-free legislation and hospitalizations for cardiac, cerebrovascular, and respiratory diseases: a meta-analysis. Circulation. 2012; 126:2177-2183 [M,II]

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ASOCIACIÓN ENTRE LEGISLACIÓN SIN HUMO Y ENFERMEDADES CARDIACAS, CEREBROVASCULARES Y RESPIRATORIAS: METAANÁLISIS

 

Guazzi M, Adams V, Conraads V, Halle M, Mezzani A, Vanhees L, et al. Clinical recommendations for cardiopulmonary exercise testing data assessment in specific patient populations. Circulation. 2012; 126:2261-2274 [R,II]

22952317

RECOMENDACIONES CLÍNICAS PARA LA VALORACIÓN DE LOS DATOS DE LAS PRUEBAS DE EJERCICIO CARDIOPULMONAR EN POBLACIONES DE PACIENTES ESPECÍFICOS

 

Rose AJ. Improving the management of warfarin may be easier than we think. Circulation. 2012; 126:2277-2279 [AO,I]

23027800

LA MEJORA DEL MANEJO DE LA WARFARINA PUEDE SER MÁS FÁCIL DE LO QUE PENSAMOS

 

Novak NL, Brownell KD. Role of policy and government in the obesity epidemic. Circulation. 2012; 126:2345-2352 [R,I]

23129701

PAPEL DE LA POLÍTICA Y EL GOBIERNO EN LA EPIDEMIA DE OBESIDAD

 

Rosenberg MA, Manning WJ. Diastolic dysfunction and risk of atrial fibrillation: a mechanistic appraisal. Circulation. 2012; 126:2353-2362 [R,I]

23129702

DISFUNCIÓN DIASTÓLICA Y RIESGO DE FIBRILACIÓN AURICULAR: VALORACIÓN MECANICISTA

 

Dentali F, Riva N, Crowther M, Turpie AG, Lip GY, Ageno W. Efficacy and safety of the novel oral anticoagulants in atrial fibrillation: a systematic review and meta-analysis of the literature. Circulation. 2012; 126:2381-2391 [M,II]

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EFICACIA Y SEGURIDAD DE LOS NUEVOS ANTICOAGULANTES ORALES EN LA FIBRILACIÓN AURICULAR: REVISIÓN SISTEMÁTICA Y METAANÁLISIS DE LA LITERATURA

 

Skalski J, Allison TG, Miller TD. The safety of cardiopulmonary exercise testing in a population with high-risk cardiovascular diseases. Circulation. 2012; 126:2465-2472 [S,I]

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LA SEGURIDAD DE LAS PRUEBAS DE EJERCICIO CARDIOPULMONAR EN UNA POBLACIÓN CON RIESGO ALTO DE ENFERMEDADES CARDIOVASCULARES

 

Shah RV, Goldfine AB. Statins and risk of new-onset diabetes mellitus. Circulation. 2012; 126:e282-e284 [AO,I]

23109518

ESTATINAS Y RIESGO DE DIABETES MELLITUS DE NUEVA APARICIÓN

 

DIABETES CARE

 

Chuengsamarn S, Rattanamongkolgul S, Luechapudiporn R, Phisalaphong C, Jirawatnotai S. Curcumin extract for prevention of type 2 diabetes. Diabetes Care. 2012; 35:2121-2127 [EC,I]

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EXTRACTO DE CÚRCUMA EN LA PREVENCIÓN DE LA DIABETES TIPO 2

 

Bergenstal RM, Rosenstock J, Arakaki RF, Prince MJ, Qu Y, Sinha VP, et al. A randomized, controlled study of once-daily LY2605541, a novel long-acting basal insulin, versus insulin glargine in basal insulin-treated patients with type 2 diabetes. Diabetes Care. 2012; 35:2140-2147 [EC,II]

22787177             R/C

ESTUDIO CONTROLADO ALEATORIZADO DE LY2605541, UNA NUEVA INSULINA BASAL DE LARGA DURACIÓN, FRENTE A INSULINA GLARGINA EN PACIENTES CON DIABETES TIPO 2 TRATADOS CON INSULINA BASAL

 

Schechter CB, Cohen HW, Shmukler C, Walker EA. Intervention costs and cost-effectiveness of a successful telephonic intervention to promote diabetes control. Diabetes Care. 2012; 35:2156-2160 [CE,I]

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COSTES DE INTERVENCIÓN Y RENTABILIDAD DE UNA INTERVENCIÓN TELEFÓNICA EXITOSA PARA PROMOVER EL CONTROL DE LA DIABETES

 

Cherney DZ, Scholey JW, Jiang S, Har R, Lai V, Sochett EB, et al. The effect of direct renin inhibition alone and in combination with ACE inhibition on endothelial function, arterial stiffness, and renal function in type 1 diabetes. Diabetes Care. 2012; 35:2324-2330 [EC,II]

22837362             R/C

EFECTO DE LA INHIBICION DIRECTA DE LA RENINA SOLA Y EN COMBINACIÓN CON IECA SOBRE LA FUNCIÓN ENDOTELIAL, LA RIGIDEZ ARTERIAL Y LA FUNCIÓN RENAL EN LA DIABETES TIPO 1

 

Valbusa F, Bonapace S, Bertolini L, Zenari L, Arcaro G, Targher G. Increased pulse pressure independently predicts incident atrial fibrillation in patients with type 2 diabetes. Diabetes Care. 2012; 35:2337-2339 [S,I]

22837366             R/C

EL INCREMENTO DE LA PRESIÓN DEL PULSO PREDICE DE MANERA INDEPENDIENTE LA INCIDENCIA DE FIBRILACIÓN AURICULAR EN PACIENTES CON DIABETES TIPO 2

 

Targher G, Zoppini G, Mantovani W, Chonchol M, Negri C, Stoico V, et al. Comparison of two creatinine-based estimating equations in predicting all-cause and cardiovascular mortality in patients with type 2 diabetes. Diabetes Care. 2012; 35:2347-2353 [S,II]

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COMPARACIÓN DE DOS ECUACIONES DE ESTIMACIÓN BASADAS EN LA CREATININA PARA PREDECIR LA MORTALIDAD CARDIOVASCULAR Y POR CUALQUIER CAUSA EN PACIENTES CON DIABETES TIPO 2

 

Sung KC, Wild SH, Kwag HJ, Byrne CD. Fatty liver, insulin resistance, and features of metabolic syndrome: relationships with coronary artery calcium in 10,153 people. Diabetes Care. 2012; 35:2359-2364 [S,I]

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HÍGADO GRASO, RESISTENCIA A LA INSULINA Y CARACTERÍSTICAS DEL SÍNDROME METABÓLICO: RELACIONES CON EL CALCIO ARTERIAL CORONARIO EN 10.153 PERSONAS

 

Haas L, Maryniuk M, Beck J, Cox CE, Duker P, Edwards L, et al; on behalf of the 2012 Standards Revision Task Force. National standards for diabetes self-management education and support. Diabetes Care. 2012; 35:2393-2401 [R,II]

22995096

ESTÁNDARES NACIONALES PARA FORMACIÓN Y APOYO EN EL AUTOMANEJO DE LA DIABETES

 

Esposito K, Chiodini P, Colao A, Lenzi A, Giugliano D. Metabolic syndrome and risk of cancer:  systematic review and meta-analysis. Diabetes Care. 2012; 35:2402-2411 [M,II]

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SÍNDROME METABÓLICO Y RIESGO DE CÁNCER: REVISIÓN SISTEMÁTICA Y METAANÁLISIS

 

DRUGS

 

Figueroa MS, Contreras I. Potential anti-vascular endothelial growth factor therapies for central retinal vein occlusion. Drugs. 2012; 72:2063-2071 [EC,I]

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TERAPIAS POTENCIALES CON FACTOR DE CRECIMIENTO ENDOTELIAL ANTIVASCULAR PARA LA OCLUSIÓN DE LA VENA CENTRAL DE LA RETINA

 

Ali FN, Carman TL. Medical management for chronic atherosclerotic peripheral arterial disease. Drugs. 2012; 72:2073-2085 [R,I]

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TRATAMIENTO MÉDICO DE LA ENFERMEDAD ARTERIAL PERIFÉRICA ATEROSCLERÓTICA CRÓNICA

 

ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA

 

Díaz-Menéndez M, Pérez-Molina JA, Serre N, Treviño B, Torrús D, Matarranz M, et al; Grupo de trabajo de +Redivi. Infecciones importadas por inmigrantes y viajeros: resultados de la Red Cooperativa para el estudio de las Enfermedades Importadas por Inmigrantes y Viajeros +Redivi. Enferm Infecc Microbiol Clin. 2012; 30:528-534 [T,I]

22409952             R/C

INFECCIONES IMPORTADAS POR INMIGRANTES Y VIAJEROS: RESULTADOS DE LA RED COOPERATIVA PARA EL ESTUDIO DE LAS ENFERMEDADES IMPORTADAS POR INMIGRANTES Y VIAJEROS +REDIVI

 

EUROPEAN HEART JOURNAL

 

Nissen SE. Cox-2 inhibitors and cardiovascular disease: considerable heat, but not much light. Eur Heart J. 2012; 33:2631-2633 [AO,I]

22711755

INHIBIDORES DE LA COX-2 Y ENFERMEDAD CARDIOVASCULAR: CALOR CONSIDERABLE, PERO NO MUCHA LUZ

 

Waeber B, Feihl F. Plasma renin levels: the lower the better in terms of cardiovascular risk? Eur Heart J. 2012; 33:2634-2635 [AO,I]

23041500

NIVELES DE RENINA EN PLASMA: ¿CUANTO MÁS BAJOS MEJOR EN TÉRMINOS DE RIESGO CARDIOVASCULAR?

 

Hindricks G, Piorkowski C. Surgical ablation of atrial fibrillation after the PRAGUE-12 study: more questions than answers. Eur Heart J. 2012; 33:2636-2638 [AO,I]

22930459

LA ABLACIÓN QUIRÚRGICA EN LA FIBRILACIÓN AURICULAR TRAS EL ESTUDIO PRAGUE-12: MÁS PREGUNTAS QUE RESPUESTAS

 

Rosenberg MA, Patton KK, Sotoodehnia N, Karas MG, Kizer JR, Zimetbaum PJ, et al. The impact of height on the risk of atrial fibrillation: the Cardiovascular Health Study. Eur Heart J. 2012; 33:2709-2717 [S,II]

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IMPACTO DE LA ALTURA SOBRE EL RIESGO DE FIBRILACIÓN AURICULAR: EL ESTUDIO DE SALUD CARDIOVASCULAR

 

Camm AJ, Lip GY, De Caterina R, Savelieva I, Atar D, Hohnloser SH, et al. 2012 focused update of the ESC Guidelines for the management of atrial fibrillation: an update of the 2010 ESC Guidelines for the management of atrial fibrillation * Developed with the special contribution of the European Heart Rhythm Association. Eur Heart J. 2012; 33:2719-2747 [M,III]

22922413

ACTUALIZACIÓN FOCALIZADA 2012 DE LAS GUÍAS ESC PARA EL MANEJO DE LA FIBRILACIÓN AURICULAR: UNA ACTUALIZACIÓN DE LAS GUÍAS ESC 2010 PARA EL MANEJO DE LA FIBRILACIÓN AURICULAR * DESARROLLADA CON LA CONTRIBUCIÓN ESPECIAL DE LA ASOCIACIÓN EUROPEA DE RITMO CARDIACO

 

Zannad F, Gattis Stough W, Rossignol P, Bauersachs J, McMurray JJ, et al. Mineralocorticoid receptor antagonists for heart failure with reduced ejection fraction: integrating evidence into clinical practice. Eur Heart J. 2012; 33:2782-2795 [R,I]

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ANTAGONISTAS DE LOS RECEPTORES DE MINERALOCORTICOIDES EN LA INSUFICIENCIA CARDIACA CON FRACCIÓN DE EYECCIÓN REDUCIDA: INTEGRAR LA EVIDENCIA EN LA PRÁCTICA CLÍNICA

 

FAMILY MEDICINE

 

Chae SY, Chae MH, Tyndall A, Ramirez MR, Winter RO. Can we effectively use the two-item PHQ-2 to screen for postpartum depression? Fam Med. 2012; 44:698-703 [T,I]

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¿PODEMOS USAR CON EFECTIVIDAD EL PHQ-2 DE 2 ELEMENTOS PARA CRIBAR LA DEPRESIÓN POSTPARTO?

 

Oyama O, Burg MA, Fraser K, Kosch SG. Mental health treatment by family physicians: current practices and preferences. Fam Med. 2012; 44:704-711 [T,I]

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TRATAMIENTO DE LA SALUD MENTAL POR MÉDICOS DE FAMILIA: PRÁCTICAS Y PREFERENCIAS ACTUALES

 

Carek PJ, Peterson L, Shokar NK, Johnson SP, Knoll ME, Mainous Iii AG. Graduate medical education and primary care workforce: a CERA study. Fam Med. 2012; 44:712-715 [T,I]

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FORMACIÓN MÉDICA EN LA LICENCIATURA Y PERSONAL DE ATENCIÓN PRIMARIA: ESTUDIO CERA

 

Carlston DL, Mattar AA, Packard J. Exploratory analysis of patients' motivations to quit smoking and participate in smoking cessation classes. Fam Med. 2012; 44:727-730 [T,I]

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ANÁLISIS EXPLORATORIO DE MOTIVACIONES DE LOS PACIENTES PARA ABANDONAR EL TABACO Y PARA PARTICIPAR EN SESIONES DE ABANDONO TABÁQUICO

 

GACETA SANITARIA

 

Alvarez C, Pastor G, Linares M, Serrano J, Rodríguez L. Motivaciones para el embarazo adolescente. Gac Sanit. 2012; 26:497-503 [C,I]

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MOTIVACIONES PARA EL EMBARAZO ADOLESCENTE

 

Rodríguez J, Traverso CI. Conductas sexuales en adolescentes de 12 a 17 años de Andalucía. Gac Sanit. 2012; 26:519-524 [T,I]

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CONDUCTAS SEXUALES EN ADOLESCENTES DE 12 A 17 AÑOS DE ANDALUCÍA

 

Chodzko-Zajko WJ, Schwingel A, Romo-Pérez V. Un análisis crítico sobre las recomendaciones de actividad física en España. Gac Sanit. 2012; 26:525-533 [T,I]

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UN ANÁLISIS CRÍTICO SOBRE LAS RECOMENDACIONES DE ACTIVIDAD FÍSICA EN ESPAÑA

 

Jiménez-Sánchez S, Fernández-de-Las-Peñas C, Carrasco-Garrido P, Hernández-Barrera V, Alonso-Blanco C, Palacios-Ceña D, et al. Prevalencia de dolor crónico de cabeza, cervical y lumbar, y factores asociados, en mujeres residentes en la Comunidad de Madrid (España) Gac Sanit. 2012; 26:534-540 [T,I]

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PREVALENCIA DE DOLOR CRÓNICO DE CABEZA, CERVICAL Y LUMBAR, Y FACTORES ASOCIADOS, EN MUJERES RESIDENTES EN LA COMUNIDAD DE MADRID (ESPAÑA)

 

Casado-Mejía R, Ruiz-Arias E, Solano-Parés A. El cuidado familiar prestado por mujeres inmigrantes y su repercusión en la calidad del cuidado y en la salud. Gac Sanit. 2012; 26:547-553 [C,I]

22464023             R/C

EL CUIDADO FAMILIAR PRESTADO POR MUJERES INMIGRANTES Y SU REPERCUSIÓN EN LA CALIDAD DEL CUIDADO Y EN LA SALUD

 

Andrés-Pretel F, Navarro B, Párraga I, de la Torre MA, Jiménez MA, López-Torres J. Conocimientos y actitudes de los mayores hacia el documento de voluntades anticipadas. Gac Sanit. 2012; 26:570-573 [T,I]

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CONOCIMIENTOS Y ACTITUDES DE LOS MAYORES HACIA EL DOCUMENTO DE VOLUNTADES ANTICIPADAS

 

Sala M, Salas D, Zubizarreta R, Ascunce N, Rué M, Castells X; en nombre de los grupos de investigación RAFP e INCA. Situación de la investigación en el cribado de cáncer de mama en España: implicaciones para la prevención. Gac Sanit. 2012; 26:574-581 [S,II]

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SITUACIÓN DE LA INVESTIGACIÓN EN EL CRIBADO DE CÁNCER DE MAMA EN ESPAÑA: IMPLICACIONES PARA LA PREVENCIÓN

 

Saigí F, Cerdá I, Guanyabens J, Carrau E. Los registros de salud personal: el caso de la Carpeta Personal de Salud de Cataluña. Gac Sanit. 2012; 26:582-584  [R,I]

22554458             R/C

LOS REGISTROS DE SALUD PERSONAL: EL CASO DE LA CARPETA PERSONAL DE SALUD DE CATALUÑA

 

GUT

 

Aziz Q. Brain-gut interactions in the regulation of satiety: new insights from functional brain imaging. Gut 2012; 61:1521-1522 [AO,I]

22661493

INTERACCIONES CEREBRO-INTESTINO EN LA REGULACIÓN DE LA SACIEDAD: NUEVAS REFLEXIONES A PARTIR DE TÉCNICAS DE IMAGEN CEREBRAL FUNCIONALES

 

JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE

 

O'Farrell CM, Green BB, Reid RJ, Bowen D, Baldwin LM. Physician-patient colorectal cancer screening discussions by physicians' screening rates. J Am Board Fam Med. 2012; 25:771-781 [C,I]

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DEBATES ENTRE MÉDICOS Y PACIENTES SOBRE EL CRIBAJE DE CÁNCER COLORRECTAL POR LAS TASAS DE CRIBAJE DE LOS MÉDICOS

 

Mold JW, Holtzclaw BJ, McCarthy L. Night sweats: a systematic review of the literature. J Am Board Fam Med. 2012; 25:878-893 [M,II]

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SUDORACIÓN NOCTURNA: REVISIÓN SISTEMÁTICA DE LA LITERATURA

 

JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

 

Sesso HD, Christen WG, Bubes V, Smith JP, MacFadyen J, Schvartz M, et al. Multivitamins in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA. 2012; 308:1751-1760 [EC,I]

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MULTIVITAMINAS EN LA PREVENCIÓN DE LA ENFERMEDAD CARDIOVASCULAR EN HOMBRES: ENSAYO CONTROLADO ALEATORIZADO PHYSICIANS' HEALTH STUDY II

 

Lonn EM. Multivitamins in prevention of cardiovascular disease. JAMA. 2012; 308:1802-1803 [AO,I]

23117781

MULTIVITAMINAS EN LA PREVENCIÓN DE LA ENFERMEDAD CARDIOVASCULAR

 

Alexander GC, Kruszewski SP, Webster DW. Rethinking opioid prescribing to protect patient safety and public health. JAMA. 2012; 308:1865-1866 [AO,I]

23150006

REPENSAR LA PRESCRIPCIÓN DE OPIOIDES PARA PROTEGER LA SEGURIDAD DE LOS PACIENTES Y LA SALUD PÚBLICA

 

Gaziano JM, Sesso HD, Christen WG, Bubes V, Smith JP, MacFadyen J, et al. Multivitamins in the prevention of cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA. 2012; 308:1871-1880 [EC,I]

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MULTIVITAMINAS EN LA PREVENCIÓN DEL CÁNCER EN HOMBRES: ENSAYO CONTROLADO ALEATORIZADO PHYSICIANS' HEALTH STUDY II

 

Palm-Meinders IH, Koppen H, Terwindt GM, Launer LJ, Konishi J, Moonen JM, et al. Structural brain changes in migraine. JAMA. 2012; 308:1889-1897 [S,II]

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CAMBIOS CEREBRALES ESTRUCTURALES EN LA MIGRAÑA

 

Bach PB, Lewis RJ. Multiplicities in the assessment of multiple vitamins: is it too soon to tell men that vitamins prevent cancer? JAMA. 2012; 308:1916-1917 [AO,I]

23150011

PLURALIDAD EN LA VALORACIÓN DE LAS VITAMINAS MÚLTIPLES: ¿ES DEMASIADO PRONTO PARA DECIRLE A LOS HOMBRES QUE LAS VITAMINAS PREVIENEN EL CÁNCER?

 

Friedman DI, Dodick DW. White matter hyperintensities in migraine: reason for optimism. JAMA. 2012; 308:1920-1921 [AO,I]

23150012

HIPERINTENSIDADES EN LA MATERIA BLANCA EN LA MIGRAÑA: RAZÓN PARA EL OPTIMISMO

 

Zafonte RD, Bagiella E, Ansel BM, Novack TA, Friedewald WT, Hesdorffer DC, et al. Effect of citicoline on functional and cognitive status among patients with traumatic brain injury: Citicoline Brain Injury Treatment Trial (COBRIT). JAMA. 2012; 308:1993-2000 [EC,I]

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EFECTO DE LA CITICOLINA SOBRE EL ESTADO FUNCIONAL Y COGNITIVO ENTRE LOS PACIENTES CON DAÑO CEREBRAL TRAUMÁTICO: ENSAYO COBRIT

 

Mozaffarian D, Marchioli R, Macchia A, Silletta MG, Ferrazzi P, Gardner TJ, et al; OPERA Investigators. Fish oil and postoperative atrial fibrillation: the Omega-3 Fatty Acids for Prevention of Post-operative Atrial Fibrillation (OPERA) randomized trial. JAMA. 2012; 308:2001-2011 [EC,I]

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ACEITE DE PESCADO Y FIBRILACIÓN AURICULAR POSTOPERATORIA: ENSAYO ALEATORIZADO OPERA

 

Gitlin LN, Kales HC, Lyketsos CG. Nonpharmacologic management of behavioral symptoms in dementia. JAMA. 2012; 308:2020-2029 [R,I]

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MANEJO NO FARMACOLÓGICO DE LOS SÍNTOMAS CONDUCTUALES EN LA DEMENCIA

 

Ruff RL, Riechers RG. Effective treatment of traumatic brain injury: learning from experience. JAMA. 2012; 308:2032-2033 [AO,I]

23168827

TRATAMIENTO EFECTIVO DEL DAÑO CEREBRAL TRAUMÁTICO: APRENDER DE LA EXPERIENCIA

 

MEDICINA CLINICA

 

Gené J, Borràs A, Contel JC, Ascaso C, González M, Gallo P; Equipo de Investigación HC>65. Factores asociados a ingreso hospitalario en una cohorte de pacientes ancianos incorporados a un programa de atención domiciliaria. Med Clin (Barc). 2012; 139:473-478 [S,I]

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FACTORES ASOCIADOS A INGRESO HOSPITALARIO EN UNA COHORTE DE PACIENTES ANCIANOS INCORPORADOS A UN PROGRAMA DE ATENCIÓN DOMICILIARIA

 

Milà R, Formiga F, Duran P, Abellana R. Prevalencia de malnutrición en la población anciana española: una revisión sistemática. Med Clin (Barc). 2012; 139:502-508 [M,II]

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PREVALENCIA DE MALNUTRICIÓN EN LA POBLACIÓN ANCIANA ESPAÑOLA: UNA REVISIÓN SISTEMÁTICA

 

Vila L, Velasco I, González S, Morales F, Sánchez E, Lailla JM, et al; el Grupo de Trabajo de Trastornos por Deficiencia de Yodo y Disfunción Tiroidea de la Sociedad Española de Endocrinología y Nutrición. Detección de la disfunción tiroidea en la población gestante: está justificado el cribado universal. Med Clin (Barc). 2012; 139:509.e1-e11 [R,II]

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DETECCIÓN DE LA DISFUNCIÓN TIROIDEA EN LA POBLACIÓN GESTANTE: ESTÁ JUSTIFICADO EL CRIBADO UNIVERSAL

 

Barneto MC, Garmendia JR, Ardura J, Casaseca JP, Andrés JM, Corral E. Relación entre infarto de miocardio y ritmo circadiano en pacientes atendidos por un servicio de emergencias prehospitalario. Med Clin (Barc). 2012; 139:515-521 [T,I]

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RELACIÓN ENTRE INFARTO DE MIOCARDIO Y RITMO CIRCADIANO EN PACIENTES ATENDIDOS POR UN SERVICIO DE EMERGENCIAS PREHOSPITALARIO

 

Miravitlles M, Llor C, Calvo E, Diaz S, Díaz-Cuervo H, Gonzalez-Rojas N. Validación de la versión traducida del Chronic Obstructive Pulmonary Disease-Population Screener (COPD-PS). Su utilidad y la del FEV1/FEV6 para el diagnóstico de enfermedad pulmonar obstructiva crónica. Med Clin (Barc). 2012; 139:522-530 [T,I]

22015009             R/C

VALIDACIÓN DE LA VERSIÓN TRADUCIDA DEL CHRONIC OBSTRUCTIVE PULMONARY DISEASE-POPULATION SCREENER (COPD-PS). SU UTILIDAD Y LA DEL FEV1/FEV6 PARA EL DIAGNÓSTICO DE ENFERMEDAD PULMONAR OBSTRUCTIVA CRÓNICA

 

Robles NR. ¿Es peligroso reducir excesivamente la presión arterial?: la curva J. Med Clin (Barc). 2012; 139:535-537 [AO,I]

22841462

¿ES PELIGROSO REDUCIR EXCESIVAMENTE LA PRESIÓN ARTERIAL?: LA CURVA J

 

Manzarbeitia J, Rodríguez L. Hipoglucemia en ancianos con diabetes. Med Clin (Barc). 2012; 139:547-552 [R,I]

22571849

HIPOGLUCEMIA EN ANCIANOS CON DIABETES

 

Ortega-Calvo M, González-García L, Corchado-Albalat Y. La E-dirección de una tesis doctoral en ciencias de la salud. Aten Primaria. 2012; 44:638-640 [AO,I]

22980945

LA E-DIRECCIÓN DE UNA TESIS DOCTORAL EN CIENCIAS DE LA SALUD

 

MORBIDITY AND MORTALITY WEEKLY REPORT

 

Divison of Global HIV/AIDS, Center for Global Health. Integrated prevention services for HIV infection, viral hepatitis, sexually transmitted diseases, and tuberculosis for persons who use drugs illicitly: summary guidance from CDC and the U.S. Department of Health and Human Services. MMWR Recomm Rep. 2012;61(RR-5):1-40 [M,III]

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SERVICIOS DE PREVENCIÓN INTEGRAL PARA LA INFECCIÓN POR VIH, HEPATITIS VÍRICA, ENFERMEDADES DE TRANSMISIÓN SEXUAL Y TUBERCULOSIS EN PERSONAS QUE USAN DROGAS ILÍCITAMENTE: GUÍA RESUMIDA DE LOS CDC Y DEL DEPARTAMENTO DE SALUD Y SERVICIOS HUMANOS DE  EE UU

 

REUMATOLOGIA CLINICA

 

Toledano E, Candelas G, Rosales Z, Martínez Prada C, León L, et al. A meta-analysis of mortality in rheumatic diseases. Reumatol Clin. 2012; 08:334-341 [M,II]

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METAANÁLISIS DE MORTALIDAD EN LAS ENFERMEDADES REUMÁTICAS

 

REVISTA ESPAÑOLA DE CARDIOLOGIA

 

Bayés de Luna A, Elosua R. Muerte súbita. Rev Esp Cardiol. 2012; 65:1039-1052 [R,II]

22959179             R/C

MUERTE SÚBITA

 

THE LANCET

 

Cardiac arrhythmias revisited. Lancet. 2012; 380:1446 [AO,I]

23101699

LAS ARRITMIAS CARDIACAS REVISITADAS

 

Camm AJ. Cardiac arrhythmias--trials and tribulations. Lancet. 2012; 380:1448-1451 [AO,I]

23101702

ARRITMIAS CARDIACAS--ENSAYOS Y TRIBULACIONES

 

Netterstrøm B. Job strain as a measure of exposure to psychological strain. Lancet. 2012; 380:1455-1456 [AO,I]

22981902

PRESIÓN LABORAL COMO MEDIDA DE EXPOSICIÓN A PRESIÓN PSICOLÓGICA

 

Kivimäki M, Nyberg ST, Batty GD, Fransson EI, Heikkilä K, Alfredsson L, et al; IPD-Work Consortium. Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data. Lancet 2012; 380:1491-1497 [M,II]

22981903             R/C

PRESIÓN LABORAL COMO FACTOR DE RIESGO DE ENFERMEDAD CARDIACA CORONARIA: METAANÁLISIS CONJUNTO CON DATOS DE PARTICIPANTES INDIVIDUALES

 

Lee G, Sanders P, Kalman JM. Catheter ablation of atrial arrhythmias: state of the art. Lancet. 2012; 380:1509-1519 [R,II]

23101718             R/C

ABLACIÓN DE ARRITMIAS AURICULARES MEDIANTE CATÉTER: LOS ÚLTIMOS AVANCES

 

John RM, Tedrow UB, Koplan BA, Albert CM, Epstein LM, Sweeney MO, et al. Ventricular arrhythmias and sudden cardiac death. Lancet. 2012; 380:1520-1529 [R,I]

23101719             R/C

ARRITMIAS VENTRICULARES Y MUERTE SÚBITA CARDIACA

 

Understanding self-harm. Lancet. 2012; 380:1532 [AO,I]

23122235

COMPRENDER LAS AUTOLESIONES

 

Health risks from toxic pollution. Lancet. 2012; 380:1532 [AO,I]

23122234

RIESGOS PARA LA SALUD DE LA CONTAMINACIÓN TÓXICA

 

Chung KF. Gabapentin: a suppressant for refractory chronic cough. Lancet. 2012; 380:1540-1541 [AO,I]

22951081

GABAPENTINA: SUPRESOR DE LA TOS CRÓNICA REFRACTARIA

 

Ryan NM, Birring SS, Gibson PG. Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial. Lancet. 2012; 380:1583-1589 [EC,I]

22951084             R/C

GABAPENTINA PARA LA TOS CRÓNICA REFRACTARIA: ENSAYO CONTROLADO CON PLACEBO, ALEATORIZADO, DOBLE CIEGO

 

Bringing postnatal depression out of the shadows. Lancet. 2012; 380:1621 [AO,I]

23141599

SACAR DE LAS SOMBRAS A LA DEPRESIÓN POSTPARTO

 

Stevens PE, Farmer CK. Association of kidney disease measures with poor outcomes. Lancet. 2012; 380:1628-1630 [AO,I]

23013601

ASOCIACIÓN DE LOS PARÁMETROS DE ENFERMEDAD RENAL CON MALOS RESULTADOS

 

The breast cancer screening debate: closing a chapter? Lancet. 2012; 380:1714 [AO,II]

23117179

EL DEBATE SOBRE EL CRIBAJE DEL CÁNCER DE MAMA: ¿CERRAR UN CAPÍTULO?

 

Engelgau MM, Gregg EW. Tackling the global diabetes burden: will screening help? Lancet. 2012; 380:1716-1718 [AO,I]

23040423

AFRONTAR LA CARGA MUNDIAL DE DIABETES: ¿AYUDARÁ EL CRIBAJE?

 

Vassiliou VS, Flynn PD. Apixaban in atrial fibrillation: does predicted risk matter? Lancet. 2012; 380:1718-1720 [AO,I]

23036897

APIXABAN EN LA FIBRILACIÓN AURICULAR: ¿IMPORTA EL RIESGO PREDICHO?

 

Simmons RK, Echouffo-Tcheugui JB, Sharp SJ, Sargeant LA, Williams KM, Prevost AT, et al. Screening for type 2 diabetes and population mortality over 10 years (ADDITION-Cambridge): a cluster-randomised controlled trial. Lancet. 2012; 380:1741-1748 [EC,I]

23040422             R/C

CRIBAJE DE DIABETES TIPO 2 Y MORTALIDAD POBLACIONAL POR ENCIMA DE LOS 10 AÑOS (ADDITION-CAMBRIDGE): ENSAYO CONTROLADO ALEATORIZADO AGRUPADO

 

Lopes RD, Al-Khatib SM, Wallentin L, Yang H, Ansell J, Bahit MC, et al. Efficacy and safety of apixaban compared with warfarin according to patient risk of stroke and of bleeding in atrial fibrillation: a secondary analysis of a randomised controlled trial. Lancet. 2012; 380:1749-1758 [EC,II]

23036896             R/C

EFICACIA Y SEGURIDAD DEL APIXABAN COMPARADO CON WARFARINA SEGÚN EL RIESGO DE ICTUS Y DE SANGRADO DEL PACIENTE EN LA FIBRILACIÓN AURICULAR: ANÁLISIS SECUNDARIO DE UN ENSAYO CONTROLADO ALEATORIZADO

 

Independent UK Panel on Breast Cancer Screening. The benefits and harms of breast cancer screening: an independent review. Lancet. 2012; 380:1778-1786 [R,II]

23117178             R/C

BENEFICIOS Y PERJUICIOS DEL CRIBAJE DE CÁNCER DE MAMA: REVISIÓN INDEPENDIENTE

 

THE NEW ENGLAND JOURNAL OF MEDICINE

 

Kesselheim AS, Avorn J, Greene JA. Risk, responsibility, and generic drugs. N Engl J Med. 2012; 367:1679-1681 [AO,I]

23113477

RIESGO, RESPONSABILIDAD Y MEDICAMENTOS GENÉRICOS

 

Nielsen SF, Nordestgaard BG, Bojesen SE. Statin use and reduced cancer-related mortality. N Engl J Med. 2012; 367:1792-1802 [S,II]

23134381             R/C

USO DE ESTATINAS Y REDUCCIÓN DE LA MORTALIDAD POR CÁNCER

 

Coenraads PJ. Hand eczema. N Engl J Med. 2012; 367:1829-1837 [R,I]

23134383

ECCEMA DE MANOS

 

Caporaso NE. Statins and cancer-related mortality--let's work together. N Engl J Med. 2012; 367:1848-1850 [AO,I]

23134387

ESTATINAS Y MORTALIDAD RELACIONADA CON CÁNCER--TRABAJEMOS JUNTOS

 

Roth EM, McKenney JM, Hanotin C, Asset G, Stein EA. Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia. N Engl J Med. 2012; 367:1891-1900 [EC,I]

23113833             R/C

ATORVASTATINA CON O SIN ANTICUERPO PARA PCSK9 EN LA HIPERCOLESTEROLEMIA PRIMARIA

 

Girotra S, Nallamothu BK, Spertus JA, Li Y, Krumholz HM, Chan PS; American Heart Association Get with the Guidelines–Resuscitation Investigators. Trends in survival after in-hospital cardiac arrest. N Engl J Med. 2012; 367:1912-1920 [S,I]

23150959             R/C

TENDENCIAS EN LA SUPERVIVENCIA TRAS PARACA CARDIACA HOSPITALARIA

 

Cerreta F, Eichler HG, Rasi G. Drug policy for an aging population--the European Medicines Agency's geriatric medicines strategy. N Engl J Med. 2012; 367:1972-1974 [AO,I]

23171092

POLÍTICA FARMACOLÓGICA PARA UNA POBLACIÓN ENVEJECIDA--LA ESTRATEGIA DE MEDICINAS GERIÁTRICAS DE LA EUROPEAN MEDICINES AGENCY

 

Brighton TA, Eikelboom JW, Mann K, Mister R, Gallus A, Ockelford P, et al; ASPIRE Investigators. Low-dose aspirin for preventing recurrent venous thromboembolism. N Engl J Med. 2012; 367:1979-1987 [EC,II]

23121403             R/C

ASPIRINA A DOSIS BAJAS PARA LA PREVENCIÓN DEL TROMBOEMBOLISMO VENOSO RECURRENTE

 

Bleyer A, Welch HG. Effect of three decades of screening mammography on breast-cancer incidence. N Engl J Med. 2012; 367:1998-2005 [S,II]

23171096             R/C

EFECTO DE TRES DÉCADAS DE CRIBAJE MAMOGRÁFICO SOBRE LA INCIDENCIA DE CÁNCER DE MAMA

 

Lichtenstein P, Halldner L, Zetterqvist J, Sjölander A, Serlachius E, Fazel S, et al. Medication for attention deficit-hyperactivity disorder and criminality. N Engl J Med. 2012; 367:2006-2014 [S,II]

23171097             R/C

MEDICACIÓN PARA EL TRASTORNO DE HIPERACTIVIDAD-DÉFICIT DE ATENCIÓN Y CRIMINALIDAD

 

Warkentin TE. Aspirin for dual prevention of venous and arterial thrombosis. N Engl J Med. 2012; 367:2039-2041 [AO,I]

23121404

ASPIRINA EN LA PREVENCIÓN DUAL DE TROMBOSIS VENOSA Y ARTERIAL

 

THORAX

 

Wedzicha JA, Donaldson GC. Natural history of successive COPD exacerbations. Thorax 2012; 67:935-936 [AO,I]

22858927

HISTORIA NATURAL DE LAS SUCESIVAS REAGUDIZACIONES DE LA EPOC

 

Suissa S, Dell'aniello S, Ernst P. Long-term natural history of chronic obstructive pulmonary disease: severe exacerbations and mortality. Thorax 2012; 67:957-963 [S,II]

22684094             R/C

HISTORIA NATURAL A LARGO PLAZO DE LA EPOC: REAGUDIZACIONES GRAVES Y MORTALIDAD

 

ANNALS OF INTERNAL MEDICINE

 

S23007881 Behavioral counseling interventions improve behavioral outcomes for adults with risky drinking.

 

S23165665 The guideline includes 48 specific recommendations that address the following issues: patient education, management of proven risk factors (dyslipidemia, hypertension, diabetes, physical activity body weight, and smoking), risk factor reduction strategies of unproven benefit, medical therapy to prevent myocardial infarction and death and to relieve symptoms, alternative therapy, revascularization to improve survival and symptoms, and patient follow-up.

 

S23128863 Low-strength evidence suggested that only a few PT interventions were effective. Future studies should compare combined PT interventions (which is how PT is generally administered for pain associated with knee osteoarthritis).

 

S22893115 The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for hearing loss in asymptomatic adults aged 50 years or older. (I statement).

 

S23165662 Previous studies have shown that HIV screening is accurate, targeted screening misses a substantial proportion of cases, and treatments are effective in patients with advanced immunodeficiency. New evidence indicates that ART reduces risk for AIDS-defining events and death in persons with less advanced immunodeficiency and reduces sexual transmission of HIV.

 

S23128861 Compared with the currently recommended strategy of continuing colonoscopy every 10 years after an initial negative examination, rescreening at age 60 years with annual HSFOBT, annual FIT, or CTC every 5 years provides approximately the same benefit in life-years with fewer complications at a lower cost. Therefore, it is reasonable to use other methods to rescreen persons with negative colonoscopy results.

 

S23128859 Use of sulfonylureas compared with metformin for initial treatment of diabetes was associated with an increased hazard of CVD events or death.

 

ARCHIVOS DE BRONCONEUMOLOGIA

 

La exposición a niveles más elevados de NO2 y O3 se asoció a un aumento del riesgo de asma y neumonía en los niños; sin embargo, el lugar en el que se determinan los contaminantes influye en los resultados. Las determinaciones realizadas en el interior y las determinaciones personales fueron las más exactas.

 

ARCHIVES OF GENERAL PSYCHIATRY

 

S22752149 Findings from these 3 registers along with consistent findings from a similar study in Denmark suggest that ASD, schizophrenia, and bipolar disorder share common etiologic factors.

 

ARCHIVES OF INTERNAL MEDICINE

 

S23147454 The PLAN clinical prediction rule identifies patients who will have a poor outcome after hospitalization for acute ischemic stroke. The score comprises clinical data available at the time of admission and may be determined by nonspecialist clinicians. Additional studies to independently validate the PLAN rule in different populations and settings are required.

 

S23007264 The use of anti-Xa or direct thrombin inhibitors is associated with a dramatic increase in major bleeding events, which might offset all ischemic benefits in patients receiving antiplatelet therapy after an ACS.

 

S23147455 Zonisamide at the daily dose of 400 mg moderately enhanced weight loss achieved with diet and lifestyle counseling but had a high incidence of adverse events

 

ATENCION PRIMARIA

 

S22704941 Las intervenciones sobre tabaquismo en AP son eficientes. Una propuesta para el abordaje del tabaquismo en AP, desde una perspectiva coste-efectiva, podría ser la IB sobre todos los fumadores e II sobre aquellos con más dificultad para abandonar.

 

S22257526 Poner de manifiesto las estrategias empleadas por la industria tabaquera para hacer frente a las medidas gubernamentales de regulación de sus productos. Evidenciar la relación existente entre la industria del tabaco y el sector de la hostelería. Constatar que los argumentos y estrategias utilizados de manera habitual por la industria hostelera han sido previamente aportados por la industria del tabaco.

Localización de documentos claves mediante metabuscadores, enlaces a sitios de documentos desclasificados, documentos de webs específicas sobre tabaco y del sector de la hostelería, fuentes periodísticas y artículos científicos publicados en revistas especializadas en salud.

Se pone en evidencia la estrecha relación entre industria del tabaco y el sector hostelero. Se ponen de manifiesto las estrategias llevadas a cabo por la industria del tabaco que incluyen acaparación de información estratégica, relaciones públicas, lobbys, programa de consultoría, grupos de defensa de los fumadores, creación de alianzas, intimidación y patrocinio. Los argumentos y estrategias utilizados por la industria de la hostelería coinciden punto por punto con los utilizados por la industria del tabaco. Estos argumentos son rebatibles desde el punto de vista de la Salud Pública, ya que científicamente está totalmente comprobado que los ambientes libres de humo son la única manera de proteger a los no fumadores de la exposición al humo del tabaco y de sus efectos nocivos sobre la salud.

 

S22296794 La producción de AP supone cerca del 1% del total de la producción científica, con un crecimiento notorio y mayor que la media en 20 años. La proporción de ensayos clínicos es similar a otras disciplinas. Aunque los países y revistas anglosajones son los más productores, España y la revista Aten Primaria se encuentra entre los destacados.

 

BRITISH JOURNAL OF PSYCHIATRY

 

S23118031 In this editorial, we propose that the association between depression and cardiovascular disease may be conceptualised as a continuous, bidirectional process that originates in youth. The paper byÅ (berg) and colleagues in this issue adds to this literature showing that low cardiovascular fitness at adolescence increases the risk of future depression.

 

S22700083 Lower cardiovascular fitness at age 18 was associated with increased risk of serious depression in adulthood. These results strengthen the theory of a cardiovascular contribution to the aetiology of depression.

 

S23118034 The findings from the meta-synthesis can help to inform the development and evaluation of psychosocial interventions in care homes and support their widespread implementation in clinical settings.

 

S22790678 Low levels of serum 25(OH)D are associated with depressive symptoms, but no effect was found with vitamin D supplementation.

 

S23118032 This editorial critiques the recent literature concerning both vitamin D deficiency in major depression and supplementation as a treatment strategy, and contextualises it within a broader approach to the prevention of depression, based on the recent evidence for lifestyle as a risk factor for depression and anxiety.

 

S23118033 The new generation of psychosocial interventions for dementia has been characterised by great improvements in methodology and high-quality randomised controlled trials, including cost-effectiveness analyses. There are a growing number of interventions with established effectiveness but despite this there can be difficulties with implementation in practice.

 

BRITISH MEDICAL JOURNAL

 

S23129488 Children gained little additional sleep on melatonin; though they fell asleep significantly faster, waking times became earlier. Child behaviour and family functioning outcomes did not significantly improve. Melatonin was tolerable over this three month period. Comparisons with slow release melatonin preparations or melatonin analogues are required.

 

S23112118 Available observational data indicate moderate, inverse associations of fish consumption and long chain omega 3 fatty acids with cerebrovascular risk. Long chain omega 3 fatty acids measured as circulating biomarkers in observational studies or supplements in primary and secondary prevention trials were not associated with cerebrovascular disease. The beneficial effect of fish intake on cerebrovascular risk is likely to be mediated through the interplay of a wide range of nutrients abundant in fish.

 

S23048011 After 10 years of randomised treatment, women receiving hormone replacement therapy early after menopause had a significantly reduced risk of mortality, heart failure, or myocardial infarction, without any apparent increase in risk of cancer, venous thromboembolism, or stroke.

 

S23150473 Compared with vitamin K antagonists, the novel oral anticoagulants had a similar risk of recurrence of acute venous thromboembolism and all cause mortality, though rivaroxaban was associated with a reduced risk of bleeding.

 

S23169868 General health checks did not reduce morbidity or mortality, neither overall nor for cardiovascular or cancer causes, although they increased the number of new diagnoses. Important harmful outcomes were often not studied or reported.

 

S23100333 The lower smoking related hazards reported previously in Japan may have been due to earlier birth cohorts starting to smoke when older and smoking fewer cigarettes per day. In Japan, as elsewhere, those who start smoking in early adult life and continue smoking lose on average about a decade of life. Much of the risk can, however, be avoided by giving up smoking before age 35, and preferably well before age 35.

 

S23169869 Low muscular strength in adolescents is an emerging risk factor for major causes of death in young adulthood, such as suicide and cardiovascular diseases. The effect size observed for all cause mortality was equivalent to that for well established risk factors such as elevated body mass index or blood pressure.

 

S23129490 For secondary prevention, apixaban, ivaroxaban, and dabigatran had broadly similar efficacy for the main endpoints, although the endpoints of haemorrhagic stroke, vascular death, major bleeding, and intracranial bleeding were less common with dabigatran 110 mg twice daily than with rivaroxaban. For primary prevention, the three drugs showed some differences in relation to efficacy and bleeding. These results are hypothesis generating and should be confirmed in a head to head randomised trial.

 

S23103369 Under base case assumptions it is unlikely that a pneumococcal vaccination programme aimed at risk groups could be considered cost effective. Uncertainty could be substantially reduced by establishing the effectiveness of the 13 valent pneumococcal conjugate vaccine against non-bacteraemic pneumococcal pneumonia, particularly in at risk groups.

 

S23138033 This cohort study found no increased risk of major cardiovascular events associated with use of varenicline compared with bupropion for smoking cessation. On the basis of the upper confidence limit, the data allowed the exclusion of a 40% increased risk of the composite outcome of any major cardiovascular event. While the estimates were less precise for specific outcomes, any differences would be small in absolute terms.

 

S23097549 Parameters for diagnostic performance significantly decrease if non-evaluable results are included by a 3×2 table for analysis (intention to diagnose approach). This approach provides a more realistic picture of the clinical potential of diagnostic tests.

 

CANADIAN MEDICAL ASOCIATION JOURNAL

 

S23071369 Not wearing a helmet while cycling was associated with an increased risk of dying as a result of sustaining a head injury (adjusted odds ratio [OR] 3.1, 95% confidence interval [CI] 1.3-7.3). We saw the same relationship when we excluded people younger than 18 years from the analysis (adjusted OR 3.5, 95% CI 1.4-8.5) and when we used a more stringent case definition (i.e., only a head injury with no other substantial injuries; adjusted OR 3.6, 95% CI 1.2-10.2).

 

S23027910 Moderate to high alcohol intake was associated with an increased incidence of atrial fibrillation among people aged 55 or older with cardiovascular disease or diabetes. Among moderate drinkers, the effect of binge drinking on the risk of atrial fibrillation was similar to that of habitual heavy drinking.

 

CIRCULATION

 

S23091065 CPX is generally a safe procedure, even in a population with underlying high-risk cardiovascular diagnoses.

S23109514 Smoke-free legislation was associated with a lower risk of smoking-related cardiac, cerebrovascular, and respiratory diseases, with more comprehensive laws associated with greater changes in risk.

S23071159 NOACs are associated with an overall clinical benefit compared with vitamin K antagonists. Additional research is required to confirm these findings outside the context of randomized trials.

 

DIABETES CARE

 

S22837366 Our findings suggest that increased PP independently predicts incident AF in patients with type 2 diabetes.

 

S22851599 The costs of a telephonic intervention for diabetes self-management support are moderate and commensurate to the modest associated improvement in glycemic control.

 

S23093685 Metabolic syndrome is associated with increased risk of common cancers; for some cancers, the risk differs betweens sexes, populations, and definitions of metabolic syndrome.

 

S22837362 In patients with uncomplicated type 1 diabetes, aliskiren-based dual RAS blockade is associated with greater arterial compliance, FMD, and renal vasodilatation.

 

S22787177 In patients with type 2 diabetes, LY2605541 and GL had comparable glucose control and total hypoglycemia rates, but LY2605541 showed reduced intraday variability, lower nocturnal hypoglycemia, and weight loss relative to GL.

 

S22837367 Our findings suggest that the estimation of GFR using the CKD-EPI equation more appropriately stratifies patients with type 2 diabetes according to the risk of all-cause and cardiovascular mortality compared with the MDRD study equation.

 

S22773702 A 9-month curcumin intervention in a prediabetic population significantly lowered the number of prediabetic individuals who eventually developed T2DM. In addition, the curcumin treatment appeared to improve overall function of ß-cells, with very minor adverse effects. Therefore, this study demonstrated that the curcumin intervention in a prediabetic population may be beneficial.

 

S22829522 Fatty liver and HOMA-IR are both associated with a CAC score >0 (independently of each other), features of MetS, conventional cardiovascular risk factors, and existing CVD.

 

DRUGS

 

S23046179 The generalized term 'peripheral vascular disease' (PVD) may be used to refer to vascular disorders in any non-coronary arterial bed. The more specific term 'peripheral arterial disease' (PAD) is used to refer to a more specific process, atherosclerotic disease of the lower extremities. PAD is common. Conservative estimates suggest more than 8?million Americans may be affected by PAD. Since atherosclerosis is a systemic process, PAD should be identified as a coronary heart disease risk equivalent. However, PAD remains an under-diagnosed and under-recognized risk for cardiovascular morbidity and mortality. PAD symptoms may range from non-specific ambulatory leg complaints, to typical symptoms of intermittent claudication to critical limb ischaemia with rest pain, gangrene or ulceration. These symptoms directly impact quality of life and may affect functional capacity. There are two therapeutic goals for patients with PAD: first, to reduce the risk of cardiovascular events and second, to manage the lower extremity symptoms. This manuscript reviews the medical management of patients with PAD, briefly discussing the goals of cardiovascular risk factor modification and then focusing on pharmacological management strategies for patients with intermittent claudication and critical limb ischaemia.

 

S23061805 Central retinal vein occlusion (CRVO) remains an important cause of visual loss. Impaired venous drainage leads to retinal hypoxia with upregulation and release of vascular endothelial growth factor (VEGF). VEGF increases vascular permeability and leads to the breakdown of the blood-retinal barrier, with the development of macular oedema. Treatment strategies for macular oedema in CRVO currently under evaluation focus on VEGF blockage. Bevacizumab is a humanized monoclonal antibody that blocks VEGF. It has been evaluated in a clinical trial that compared intravitreal injections of bevacizumab 1.25?mg with sham injections every 6 weeks. At the end of a 24-week follow-up period, 60.0% of patients in the bevacizumab group had gained =15 letters compared with 20.0% in the control group (p?=?0.003). Aflibercept (previously VEGF Trap-Eye) is a 115?kD decoy receptor fusion protein. Aflibercept is capable of binding both VEGF and placental growth factor (PlGF). By blocking both VEGF and PlGF, aflibercept could be more effective than other anti-VEGF drugs. Two clinical trials have evaluated the efficacy of aflibercept for the treatment of macular oedema in CRVO: COPERNICUS and GALILEO. Both included a similar 6-month phase, during which patients were randomized to receive either an intravitreal injection of aflibercept 2?mg or a sham injection every month. In a second 6-month phase of the GALILEO study, patients in the treatment group were treated on an as needed (PRN) basis with aflibercept, while patients in the placebo group continued with sham injections. In the second 6-month phase in the COPERNICUS study, all patients were treated with aflibercept on a PRN basis. Treatment with aflibercept led to an improvement in visual acuity of =15 letters in 55.3% (COPERNICUS) and 60.2% of patients (GALILEO). Patients initially in the placebo group and then treated PRN gained only a mean of 3.8 letters, with 30.1% achieving a visual gain of =15 letters (COPERNICUS). The percentage of patients that improved by =15 letters was 32.4% for the group receiving sham injections throughout the GALILEO study. In summary, VEGF blockage has been proven to improve visual outcomes in patients with macular oedema due to CRVO. However, an important disadvantage of anti-VEGF drugs is the need for frequent reinjections and even more frequent control visits. Further advances are needed in order to improve quality of life and reduce the burden to healthcare systems.

 

ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA

 

S22409952 La red +Redivi permite conocer y cuantificar las infecciones importadas por inmigrantes y viajeros, su origen geográfico, el tipo de paciente que las padece y su patrón temporal. Los datos preliminares de la red muestran la presencia significativa de enfermedades transmisibles y con potencial reintroducción en nuestro medio, así como la importancia del cribado sistemático en sujetos que proceden de zonas tropicales. El objetivo de +Redivi es el de evaluar el impacto de la patología importada en España con el fin de contribuir a la mejora en la asistencia a los pacientes e incidir en la prevención y el tratamiento de las enfermedades importadas más prevalentes, y detectar la posible existencia de brotes epidémicos.

 

EUROPEAN HEART JOURNAL

 

S22942339 Mineralocorticoid receptor antagonists (MRAs) improve survival and reduce morbidity in patients with heart failure, reduced ejection fraction (HF-REF), and mild-to-severe symptoms, and in patients with left ventricular systolic dysfunction and heart failure after acute myocardial infarction. These clinical benefits are observed in addition to those of angiotensin converting enzyme inhibitors or angiotensin receptor blockers and beta-blockers. The morbidity and mortality benefits of MRAs may be mediated by several proposed actions, including antifibrotic mechanisms that slow heart failure progression, prevent or reverse cardiac remodelling, or reduce arrhythmogenesis. Both eplerenone and spironolactone have demonstrated survival benefits in individual clinical trials. Pharmacologic differences exist between the drugs, which may be relevant for therapeutic decision making in individual patients. Although serious hyperkalaemia events were reported in the major MRA clinical trials, these risks can be mitigated through appropriate patient selection, dose selection, patient education, monitoring, and follow-up. When used appropriately, MRAs significantly improve outcomes across the spectrum of patients with HF-REF.

 

S22977225 Independent from sex, increased height is significantly associated with the risk of AF.

 

FAMILY MEDICINE

 

S23148003 While numerous recommendations have recently been made, most responding FMRD feel that changing reimbursement for primary care physicians would have the greatest impact on the workforce.

 

S23148007 Based on the current research, physicians are encouraged to follow practice guidelines, asking all patients about smoking behavior and assisting in their efforts to quit, especially those who have previously been unsuccessful in the past.

 

S23148001 This study supports previous findings indicating that the PHQ-2 can be an effective tool in screening for postpartum depression.

 

S23148002 Physicians are willing and feel competent to identify and treat patients with mental disorders in the family medicine outpatient setting, including the provision of brief office counseling. Further research is needed to understand what effective mental health interventions can efficiently be taught to family physicians. Having family physicians treat mental health disorders may lead to greater patient satisfaction, improved chronic care management, and a positive impact on quality of care.

 

GACETA SANITARIA

 

S22444520 Los mayores muestran una actitud positiva hacia las voluntades anticipadas, pero la proporción de personas que conocen el documento es baja.

 

S22483409 Uno de cada seis estudiantes de ESO de Andalucía ha mantenido relaciones sexuales con penetración; de ellos, dos tercios las mantienen en la actualidad, sobre todo las chicas. Valorado junto con un escaso conocimiento (menos del 50%) del doble método y de las infecciones de transmisión sexual, nos lleva a considerar necesario incluir la educación sexual como específica dentro del currículo de la enseñanza secundaria.

 

S22464023 El cuidado familiar encargado a mujeres inmigrantes, unido al duelo migratorio, tiene importantes repercusiones en su salud. Si las relaciones interpersonales son de buen trato e igualitarias, se constituyen como factor de protección para todas las personas en contacto.

 

S22554458 Este trabajo explora las posibilidades de la Carpeta Personal de Salud e identifica la brecha entre el potencial de esta herramienta y las aplicaciones que ofrece a través de Internet. Se presenta la Carpeta Personal de Salud, un proyecto vinculado a la Historia Clínica Compartida de Cataluña, que ofrece un punto de acceso a la información sobre la propia salud que es seguro, personalizado y soportado por las tecnologías de la información y la comunicación. La experiencia, realizada íntegramente por la Consejería de Salud de la Generalitat de Cataluña, escogió una metodología mediante encuesta anónima. Los resultados han sido de gran relevancia para obtener información sobre la idoneidad de los datos publicados y las expectativas de una herramienta dirigida a la población en general.

 

S22342049 Este estudio encontró que el dolor crónico de cabeza, cervical y lumbar es un problema de salud en las mujeres, ya que presentan mayor prevalencia de dolor que los hombres. El dolor se asocia a un mayor consumo de fármacos y de recursos sanitarios.

 

S22424970 Estos resultados se incorporarán a los modelos matemáticos sobre evaluación de la eficiencia de los programas que se están desarrollando actualmente. Modelos que pueden ser de gran utilidad como herramienta dirigida a informar y guiar las decisiones clínicas y de planificación sanitaria sobre el control del cáncer.

 

S22361642 Las recomendaciones hacen referencia a la actividad física aeróbica y apenas tienen en cuenta el fortalecimiento muscular. Una comunidad autónoma se ajusta a las recomendaciones de la OMS. Las comunidades con mayores índices de envejecimiento y mayor porcentaje de infancia/adolescentes casi no hacen recomendaciones sobre actividad física de acuerdo con las directrices de la OMS.

 

S22521341 El contexto familiar y de socialización de las chicas se basa en una distribución tradicional de roles en función del género, en el cual posicionamiento y rol tradicional de mujer cuidadora está muy interiorizado. Las motivaciones para el embarazo adolescente no están claras; hay una falta de sentido de la autodeterminación y son las circunstancias las que deciden.

 

JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE

 

S23136329 The symptom, night sweats, appears to be nonspecific. Many questions about causation, evaluation, and management remain unanswered.

 

S23136315 Encouraging providers to use risk-specific messaging about the consequences of CRC, offering screening option choices, and promoting a problem-solving approach to surmount barriers are potential strategies for increasing CRC screening rates.

 

JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

 

S23128104 In this large multinational trial among patients undergoing cardiac surgery, perioperative supplementation with n-3-PUFAs, compared with placebo, did not reduce the risk of postoperative AF.

 

S23168823 Among patients with traumatic brain injury, the use of citicoline compared with placebo for 90 days did not result in improvement in functional and cognitive status.

 

S23162860 In this large prevention trial of male physicians, daily multivitamin supplementation modestly but significantly reduced the risk of total cancer.

 

S23168825 Behavioral symptoms such as repetitive speech, wandering, and sleep disturbances are a core clinical feature of Alzheimer disease and related dementias. If untreated, these behaviors can accelerate disease progression, worsen functional decline and quality of life, cause significant caregiver distress, and result in earlier nursing home placement. Systematic screening for behavioral symptoms in dementia is an important prevention strategy that facilitates early treatment of behavioral symptoms by identifying underlying causes and tailoring a treatment plan. First-line nonpharmacologic treatments are recommended because available pharmacologic treatments are only modestly effective, have notable risks, and do not effectively treat some of the behaviors that family members and caregivers find most distressing. Examples of nonpharmacologic treatments include provision of caregiver education and support, training in problem solving, and targeted therapy directed at the underlying causes for specific behaviors (eg, implementing nighttime routines to address sleep disturbances). Based on an actual case, we characterize common behavioral symptoms and describe a strategy for selecting evidence-based nonpharmacologic dementia treatments. Nonpharmacologic management of behavioral symptoms in dementia can significantly improve quality of life and patient-caregiver satisfaction.

 

S23117775 Among this population of US male physicians, taking a daily multivitamin did not reduce major cardiovascular events, MI, stroke, and CVD mortality after more than a decade of treatment and follow-up.

 

S23150008 In a community-based cohort followed up after 9 years, women with migraine had a higher incidence of deep white matter hyperintensities but did not have significantly higher progression of other MRI-measured brain changes. There was no association of migraine with progression of any MRI-measured brain lesions in men.

 

MEDICINA CLINICA

 

S22015009 El cuestionario COPD-PS demostró buenas propiedades psicométricas. Un punto de corte 4 presenta propiedades predictivas óptimas. El cociente FEV1/FEV6<0,75 ofrece una excelente correlación con el cociente FEV1/FVC y es útil para el cribado de obstrucción crónica al flujo aéreo.

 

S22981085 There is a controversy among different scientific societies in relation to the recommendations on whether universal screening for the detection of thyroid dysfunction during gestation should be performed or not. Although various studies have shown an association between subclinical hypothyroidism or hypothyroxinemia with obstetric problems and/or neurocognitive impairment in the offspring, no evidence on the possible positive effects of treatment of such conditions with thyroxin has been demonstrated so far. However, there is a general agreement about the need for treatment of clinical hypothyroidism during pregnancy and the risks of not doing so. Because it is a common, easily diagnosed and effectively treated disorder without special risk, the working Group of Iodine Deficiency Disorders and Thyroid Dysfunction of the Spanish Society of Endocrinology and Nutrition and Spanish Society of Gynaecology and Obstetrics recommends an early evaluation (before week 10) of thyroid function in all pregnant women. Given the complex physiology of thyroid function during pregnancy, hormone assessment should be performed according to reference values for each gestational trimester and generated locally in each reference laboratory. Thyrotropin determination would be sufficient for screening purposes and only if it is altered, free thyroxin or total thyroxin would be required. Adequate iodine nutrition is also highly recommended before and during pregnancy to contribute to a normal thyroid function in the pregnant women and fetus.

S22592080 Hospital admission among EDLH patients is related to comorbidity, gender, subjective health status and the use of uncoordinated emergency services as measured at recruitment, rather than to the use of services during the one-year follow-up.

 

S22206796 El infarto de miocardio presenta ritmo circadiano. El tabaquismo y la diabetes modifican el patrón de ritmo circadiano habitual del infarto.

 

S22677049 En los últimos años, varios estudios han estimado la prevalencia de malnutrición en la población anciana. El objetivo de esta revisión sistemática es obtener una visión global sobre el estado nutricional de la población anciana. Esta revisión se ha basado en la recopilación de estudios con información sobre la prevalencia de malnutrición publicados entre 1995-2011. Un total de 43.235 ancianos procedentes de 47 trabajos han sido seleccionados. Según el Mini Nutritional Assessment, se observó un 16,6% (intervalo de confianza del 95% [IC 95%] 0-62) de malnutrición; con los parámetros antropométricos o bioquímicos, se observó un 21,4% (IC 95% 2-77,3) de malnutrición; y con otros índices de evaluación nutricional, se observó una malnutrición de 47,3% (IC 95% 10,6-94,7). Las tasas de prevalencia de desnutrición fueron más altas en los estudios con gran proporción de pacientes con discapacidad grave, fractura de cadera o problemas de deglución. Se puede concluir que la malnutrición entre la población anciana está generalizada y es muy variable en función de los parámetros utilizados, los problemas de salud asociados o el ámbito de la población. En los futuros estudios, el uso sistemático de cribados nutricionales en los hospitales, residencias o centros asistenciales mejoraría mucho el pronóstico y la calidad de vida de las personas mayores, y facilitaría la comparación entre los resultados de los estudios.

 

MORBIDITY AND MORTALITY WEEKLY REPORT

 

S23135062 This report summarizes current (as of 2011) guidelines or recommendations published by multiple agencies of the U.S. Department of Health and Human Services (DHHS) for prevention and control of human immunodeficiency virus (HIV) infection, viral hepatitis, sexually transmitted diseases (STDs), and tuberculosis (TB) for persons who use drugs illicitly. It also summarizes existing evidence of effectiveness for practices to support delivery of integrated prevention services. Implementing integrated services for prevention of HIV infection, viral hepatitis, STDs, and TB is intended to provide persons who use drugs illicitly with increased access to services, to improve timeliness of service delivery, and to increase effectiveness of efforts to prevent infectious diseases that share common risk factors, behaviors, and social determinants. This guidance is intended for use by decision makers (e.g., local and federal agencies and leaders and managers of prevention and treatment services), health-care providers, social service providers, and prevention and treatment support groups. Consolidated guidance can strengthen efforts of health-care providers and public health providers to prevent and treat infectious diseases and substance use and mental disorders, use resources efficiently, and improve health-care services and outcomes in persons who use drugs illicitly. An integrated approach to service delivery for persons who use drugs incorporates recommended science-based public health strategies, including 1) prevention and treatment of substance use and mental disorders; 2) outreach programs; 3) risk assessment for illicit use of drugs; 4) risk assessment for infectious diseases; 5) screening, diagnosis, and counseling for infectious diseases; 6) vaccination; 7) prevention of mother-to-child transmission of infectious diseases; 8) interventions for reduction of risk behaviors; 9) partner services and contact follow-up; 10) referrals and linkage to care; 11) medical treatment for infectious diseases; and 12) delivery of integrated prevention services. These strategies are science-based, public health strategies to prevent and treat infectious diseases, substance use disorders, and mental disorders. Treatment of infectious diseases and treatment of substance use and mental disorders contribute to prevention of transmission of infectious diseases. Integrating prevention services can increase access to and timeliness of prevention and treatment.

 

REUMATOLOGIA CLINICA

 

S22789463 Based on our results and on the good quality of the included studies, we can conclude that rheumatic diseases increase in general the risk of death, and especially inflammatory diseases.

 

REVISTA ESPAÑOLA DE CARDIOLOGIA

 

S22959179 La muerte súbita probablemente sea el desafío más importante de la cardiología moderna. En este artículo, después de realizar una revisión histórica de la muerte súbita, se comentan la epidemiología y las enfermedades asociadas a ella y se hace énfasis en los aspectos fisiopatológicos, especialmente los factores desencadenantes que actuando sobre un miocardio vulnerable precipitan la arritmia final, que en general lleva a la fibrilación ventricular y en menor medida a bradiarritmia y muerte súbita. Se comentan especialmente la importancia de la isquemia aguda y la disfunción ventricular y el papel de la genética, no sólo en las cardiopatías de origen genético, sino también su posible efecto desencadenante en la cardiopatía isquémica aguda y crónica. Por último, se describe cuál es la mejor forma de identificar a los pacientes en riesgo, cómo prevenir la muerte súbita y qué conducta seguir ante un paciente resucitado de una parada cardiaca.

 

THE LANCET

 

S23101718 Catheter ablation is at the forefront of the management of a range of atrial arrhythmias. In this Series paper, we discuss the underlying mechanisms and the current role of catheter ablation for the three most common atrial arrhythmias encountered in clinical practice: focal atrial tachycardia, atrial flutter, and atrial fibrillation. The mechanisms of focal atrial tachycardia and atrial flutter are well understood, and these arrhythmias are amenable to curative catheter ablation with high success rates. In most cases, paroxysmal atrial fibrillation is initiated by triggers located within pulmonary vein musculature. Circumferential ablation to isolate this musculature is associated with high success rates for elimination of paroxysmal atrial fibrillation in selected populations. Because of the problem of recurrent pulmonary vein connection, more than one procedure will be needed in about 30% of patients, and new technologies are being developed to reduce this occurrence. The mechanisms that sustain persistent atrial fibrillation are not well understood and are the subject of continuing investigation. As such, ablation approaches and technologies for this arrhythmia are still evolving.

 

S23036896 Because apixaban has benefits over warfarin that are consistent across patient risk of stroke and bleeding as assessed by the CHADS2, CHA2DS2VASc, and HAS-BLED scores, these scores might be less relevant when used to tailor apixaban treatment to individual patients than they are for warfarin. Further improvement in risk stratification for both stroke and bleeding is needed, particularly for patients with atrial fibrillation at low risk for these events.

 

S22951084 The treatment of refractory chronic cough with gabapentin is both effective and well tolerated. These positive effects suggest that central reflex sensitisation is a relevant mechanism in refractory chronic cough.

 

S22981903 Our findings suggest that prevention of workplace stress might decrease disease incidence; however, this strategy would have a much smaller effect than would tackling of standard risk factors, such as smoking.

 

S23117178 Whether breast cancer screening does more harm than good has been debated extensively. The main questions are how large the benefit of screening is in terms of reduced breast cancer mortality and how substantial the harm is in terms of overdiagnosis, which is defined as cancers detected at screening that would not have otherwise become clinically apparent in the woman's lifetime. An independent Panel was convened to reach conclusions about the benefits and harms of breast screening on the basis of a review of published work and oral and written evidence presented by experts in the subject. To provide estimates of the level of benefits and harms, the Panel relied mainly on findings from randomised trials of breast cancer screening that compared women invited to screening with controls not invited, but also reviewed evidence from observational studies. The Panel focused on the UK setting, where women aged 50-70 years are invited to screening every 3 years. In this Review, we provide a summary of the full report on the Panel's findings and conclusions. In a meta-analysis of 11 randomised trials, the relative risk of breast cancer mortality for women invited to screening compared with controls was 0·80 (95% CI 0·73-0·89), which is a relative risk reduction of 20%. The Panel considered the internal biases in the trials and whether these trials, which were done a long time ago, were still relevant; they concluded that 20% was still a reasonable estimate of the relative risk reduction. The more reliable and recent observational studies generally produced larger estimates of benefit, but these studies might be biased. The best estimates of overdiagnosis are from three trials in which women in the control group were not invited to be screened at the end of the active trial period. In a meta-analysis, estimates of the excess incidence were 11% (95% CI 9-12) when expressed as a proportion of cancers diagnosed in the invited group in the long term, and 19% (15-23) when expressed as a proportion of the cancers diagnosed during the active screening period. Results from observational studies support the occurrence of overdiagnosis, but estimates of its magnitude are unreliable. The Panel concludes that screening reduces breast cancer mortality but that some overdiagnosis occurs. Since the estimates provided are from studies with many limitations and whose relevance to present-day screening programmes can be questioned, they have substantial uncertainty and should be regarded only as an approximate guide. If these figures are used directly, for every 10,000 UK women aged 50 years invited to screening for the next 20 years, 43 deaths from breast cancer would be prevented and 129 cases of breast cancer, invasive and non-invasive, would be overdiagnosed; that is one breast cancer death prevented for about every three overdiagnosed cases identified and treated. Of the roughly 307,000 women aged 50-52 years who are invited to begin screening every year, just over 1% would have an overdiagnosed cancer in the next 20 years. Evidence from a focus group organised by Cancer Research UK and attended by some members of the Panel showed that many women feel that accepting the offer of breast screening is worthwhile, which agrees with the results of previous similar studies. Information should be made available in a transparent and objective way to women invited to screening so that they can make informed decisions.

 

S23101719 Management strategies for ventricular arrhythmias are guided by the risk of sudden death and severity of symptoms. Patients with a substantial risk of sudden death usually need an implantable cardioverter defibrillator (ICD). Although ICDs effectively end most episodes of ventricular tachycardia or ventricular fibrillation and decrease mortality in specific populations of patients, they have inherent risks and limitations. Generally, antiarrhythmic drugs do not provide sufficient protection from sudden death, but do have a role in reducing arrhythmias that cause symptoms. Catheter ablation is likewise important for reducing the frequency of spontaneous arrhythmias and is curative for some patients, usually those with idiopathic arrhythmias and no heart disease. Arrhythmia surgery is now infrequent, offered by only a few specialised centres for refractory arrhythmias. Advances in understanding of genetic arrhythmia syndromes and in technology for mapping and ablation of ventricular arrhythmias, and enhanced algorithms in implantable devices for rhythm management, have contributed to improved outcomes.

 

S23040422 In this large UK sample, screening for type 2 diabetes in patients at increased risk was not associated with a reduction in all-cause, cardiovascular, or diabetes-related mortality within 10 years. The benefits of screening might be smaller than expected and restricted to individuals with detectable disease.

 

 

THE NEW ENGLAND JOURNAL OF MEDICINE

 

S23113833 In a randomized trial involving patients with primary hypercholesterolemia, adding SAR236553 to either 10 mg of atorvastatin or 80 mg of atorvastatin resulted in a significantly greater reduction in LDL cholesterol than that attained with 80 mg of atorvastatin alone.

 

S23171096 Despite substantial increases in the number of cases of early-stage breast cancer detected, screening mammography has only marginally reduced the rate at which women present with advanced cancer. Although it is not certain which women have been affected, the imbalance suggests that there is substantial overdiagnosis, accounting for nearly a third of all newly diagnosed breast cancers, and that screening is having, at best, only a small effect on the rate of death from breast cancer.

 

S23121403 In this study, aspirin, as compared with placebo, did not significantly reduce the rate of recurrence of venous thromboembolism but resulted in a significant reduction in the rate of major vascular events, with improved net clinical benefit. These results substantiate earlier evidence of a therapeutic benefit of aspirin when it is given to patients after initial anticoagulant therapy for a first episode of unprovoked venous thromboembolism.

 

S23171097 Among patients with ADHD, rates of criminality were lower during periods when they were receiving ADHD medication. These findings raise the possibility that the use of medication reduces the risk of criminality among patients with ADHD.

 

S23150959 Both survival and neurologic outcomes after in-hospital cardiac arrest have improved during the past decade at hospitals participating in a large national quality-improvement registry.

 

S23134381 Statin use in patients with cancer is associated with reduced cancer-related mortality. This suggests a need for trials of statins in patients with cancer.

 

THORAX

 

S22684094 The course of COPD involves a rapid decline in health status after the second severe exacerbation and high mortality in the weeks following every severe exacerbation. Two strategic targets for COPD management should include delaying the second severe exacerbation and improving treatment of severe exacerbations to reduce their excessive early mortality.

 

 

 

                      

 

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